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Association Between the Apolipoprotein E Gene Polymorphism and Atherosclerotic Middle Cerebral Artery Stenosis

Zhengsheng Zhang1,2, Xiang-Yan Chen2, Larry Baum3

  • 1Neurologic Department of Affiliated ZhongDa Hospital, Neuropsychiatric Institute and Medical School of Southeast University, Nanjing, Jiangsu.

The Neurologist
|March 2, 2018
PubMed
Abstract

Insights

Hypertension and the apolipoprotein E (ApoE) ε4/ε4 genotype may be linked to middle cerebral artery (MCA) stenosis in Chinese ischemic stroke patients. Further research is needed to confirm these associations.

Area of Science:

  • Neurology
  • Genetics
  • Cardiovascular Science

Background:

  • Intracranial large artery stenosis, particularly in the middle cerebral artery (MCA), is prevalent in the Chinese population.
  • Atherosclerosis in the MCA is a significant risk factor for ischemic stroke.

Purpose of the Study:

  • To investigate the clinical factors and apolipoprotein E (ApoE) gene polymorphism associated with MCA atherosclerosis in Chinese patients.
  • To compare clinical parameters and ApoE genotypes between patients with and without MCA stenosis.

Main Methods:

  • A case-control study involving 337 ischemic stroke patients (156 with MCA stenosis, 181 without).
  • Polymerase chain reaction (PCR) was used to determine ApoE gene polymorphism genotypes.
  • Clinical data, including blood pressure, and ApoE genotypes were analyzed.

Main Results:

  • Patients with MCA stenosis exhibited higher systolic and pulse pressures.
  • No significant differences in overall ApoE genotype and allele frequencies were found between groups.
  • A trend suggested a higher prevalence of the ApoE ε4/ε4 genotype in the MCA stenosis group (3.8% vs. 0.6%, P=0.052).

Conclusions:

  • Hypertension, indicated by elevated systolic and pulse pressures, is associated with MCA stenosis in Chinese ischemic stroke patients.
  • The apolipoprotein E ε4/ε4 genotype may also be associated with MCA stenosis occurrence.
  • No significant interaction between ApoE genotype and environmental factors was observed for ischemic stroke susceptibility.

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