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Electrochemical sensors and biosensors for the analysis of antineoplastic drugs

Handerson Rodrigues Silva Lima1, Josany Saibrosa da Silva1, Emanuel Airton de Oliveira Farias2

  • 1Núcleo de Tecnologia Farmacêutica, Universidade Federal do Piauí, Teresina, PI 64049-550, Brazil.

Biosensors & Bioelectronics
|March 2, 2018
PubMed

Insights

Monitoring toxic antineoplastic drugs is crucial. Electrochemical sensors and biosensors offer a practical, low-cost method for detecting these cancer treatments, with significant health and financial benefits.

Area of Science:

  • Analytical Chemistry
  • Biomedical Engineering
  • Environmental Science

Background:

  • Antineoplastic drugs are vital cancer treatments but pose significant toxicity risks to humans and the environment.
  • Effective monitoring of antineoplastic drugs at low concentrations is essential due to their hazardous nature.
  • Electrochemical sensors and biosensors present a practical and cost-effective alternative to traditional analytical methods.

Purpose of the Study:

  • To provide a comprehensive overview of electrochemical sensors and biosensors for antineoplastic drug analysis.
  • To detail the analytical performance, including limit of detection (LOD) and linear range of quantification (LR), of various sensor systems.
  • To explore the technological prospects and patent landscape for electrochemical monitoring of antineoplastic drugs.

Main Methods:

  • Review of existing literature on electrochemical sensors and biosensors for antineoplastic drug detection.
  • Analysis of methodologies used for electrochemical sensing and drug quantification.
  • Examination of analytical performance metrics (LOD, LR) for different sensor systems.
  • Patent database search for antineoplastic drug quantification technologies.

Main Results:

  • Identified and described various electrochemical sensors and biosensors developed for antineoplastic drug analysis.
  • Detailed the analytical performance, including LOD and LR, for each reviewed sensor system.
  • Found no existing patents for electrochemical monitoring of antineoplastic drugs, indicating a gap in the field.

Conclusions:

  • Electrochemical sensors and biosensors are promising tools for the sensitive and cost-effective monitoring of antineoplastic drugs.
  • The field shows significant potential for growth, with limited patent activity suggesting opportunities for innovation.
  • Advancements in this area could lead to substantial financial and health benefits through improved drug monitoring.
Keywords:
AnticancerAntineoplasticBiosensorChemotherapyElectrochemical sensor

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