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Therapeutics in Osteoarthritis Based on an Understanding of Its Molecular Pathogenesis

Ju-Ryoung Kim1, Jong Jin Yoo2, Hyun Ah Kim3

  • 1Rheumatology Division, Department of Internal Medicine, Hallym University Sacred Heart Hospital, 896, Pyongchondong, Dongan-gu, Anyang, Kyunggi-do 431-070, Korea. jurykim75@gmail.com.

International Journal of Molecular Sciences
|March 3, 2018
PubMed

Insights

Osteoarthritis (OA) is a common joint disease causing cartilage destruction and pain. This review explores new treatments targeting OA's molecular causes and associated tissue changes.

Area of Science:

  • Rheumatology
  • Molecular Biology
  • Pharmacology

Background:

  • Osteoarthritis (OA) is the most common joint disease in the elderly.
  • It involves progressive articular cartilage destruction, synovial inflammation, subchondral bone alterations, and pain.
  • Current understanding of OA's aetiopathogenesis is incomplete, hindering curative treatments.

Purpose of the Study:

  • To review novel therapeutics for OA.
  • To highlight recent advancements in understanding OA's molecular pathogenesis.
  • To examine pro-inflammatory and pro-catabolic mediators and signaling pathways in OA.

Main Methods:

  • Literature review of recent scientific progress in OA.
  • Analysis of molecular pathogenesis, including mediators and signaling mechanisms.
  • Review of changes in subchondral bone and peri-articular muscle.

Main Results:

  • Novel therapeutic strategies are emerging based on molecular insights.
  • Understanding of key pro-inflammatory and pro-catabolic pathways is advancing.
  • Associated changes in bone and muscle are being integrated into therapeutic considerations.

Conclusions:

  • Targeting molecular pathways offers promising avenues for OA treatment.
  • A comprehensive approach addressing cartilage, bone, and muscle is needed.
  • Further research into OA pathogenesis will drive the development of effective therapies.
Keywords:
articular cartilagemolecular pathologyosteoarthritis (OA)therapeutics

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