Related Experiment Video
Updated: Feb 13, 2026
08:15
Fabrication of Tongue Extracellular Matrix and Reconstitution of Tongue Squamous Cell Carcinoma In Vitro
Published on: June 20, 2018
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Do we need a different staging system for tongue and gingivobuccal complex squamous cell cancers?
Piyush Gupta1, Jocelyn C Migliacci1, Pablo H Montero1
1Department of Surgery, Head and Neck Service, Memorial Sloan Kettering Cancer Center (MSK), New York, NY 10065, United States.
Oral Oncology
|March 3, 2018
Summary
Gingivobuccal complex squamous cell cancers (GBCSCC) do not require a separate staging system. Survival outcomes for GBCSCC are similar to oral tongue squamous cell cancers (TSCC) when staged using current guidelines.
Area of Science:
- Oncology
- Cancer Research
- Head and Neck Surgery
Background:
- Squamous cell carcinoma (SCC) of the oral cavity presents unique challenges in staging and treatment.
- The gingivobuccal complex (GBC) and oral tongue are distinct subsites within the oral cavity, potentially influencing cancer behavior and outcomes.
Purpose of the Study:
- To evaluate whether gingivobuccal complex squamous cell cancers (GBCSCC) necessitate a distinct staging system compared to oral tongue squamous cell cancers (TSCC).
- To analyze 5-year overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) for GBCSCC versus TSCC.
Main Methods:
- Retrospective analysis of 936 TSCC and 486 GBCSCC patients treated between 1985 and 2012.
- Patients were staged using the American Joint Committee on Cancer 7th edition criteria.
- Multivariate analysis was employed to assess subsite as an independent predictor of survival outcomes.
Main Results:
- GBCSCC patients were older and presented with more advanced disease than TSCC patients.
- Unadjusted analysis indicated poorer OS for GBCSCC, but this was not significant after adjusting for other variables.
- No significant differences in 5-year DSS or RFS were observed between the GBCSCC and TSCC groups.
Conclusions:
- Current staging systems adequately capture survival outcomes for both GBCSCC and TSCC.
- There is no statistical justification for a separate staging system for GBCSCC based on survival data.
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