Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

Tissues

Tissues

Cells with similar structure and function are grouped into tissues. A group of tissues with a specialized function is called an organ. There are four main types of tissue in vertebrates: epithelial, connective, muscle, and nervous.

Tissues

Tissues

Tissues are a group of cells that share a common embryonic origin. Microscopic observation reveals that the cells in a tissue share morphological features and are arranged in an orderly pattern to perform specific functions. From an evolutionary perspective, tissues appear in more complex organisms. Although there are many types of cells in the human body, they are organized into four broad categories of tissues: epithelial, connective, muscle, and nervous. Each of these categories is...

Pedigree Analysis

Pedigree Analysis

Biodiversity and Human Values

Biodiversity and Human Values

Human civilization relies on biodiversity in many ways. Sudden changes in species biodiversity result in environmental changes that can modify weather patterns and therefore human civilizations.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Sensitive periods for prenatal alcohol exposure shape internalizing symptoms across development.

medRxiv : the preprint server for health sciences·2026

Same author

Authors' response.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026

Same author

Patterns of Chronic Stress in Diurnal Salivary Cortisol Already Predict Epigenetic Age Acceleration in Young Adults in the Cebu Longitudinal Health and Nutrition Survey.

American journal of human biology : the official journal of the Human Biology Council·2026

Same author

Strong concordance of DNA methylation measures between venous and capillary blood - Implications for human epigenome studies.

iScience·2026

Same author

Rtt107 cooperates with Rad55 to limit specific types of genome instability in Saccharomyces cerevisiae.

DNA repair·2026

Same author

Differing normative reference ranges for body composition and physical performance measures in Hong Kong Chinese and Canadian older adults: the Hong Kong Os study and the Canadian Longitudinal Study on Aging.

The British journal of nutrition·2026

Search research articles

Related Experiment Video

Updated: Feb 13, 2026

Neuronal Nuclei Isolation from Human Postmortem Brain Tissue

Neuronal Nuclei Isolation from Human Postmortem Brain Tissue

Published on: October 1, 2008

Epigenetic analysis of human postmortem brain tissue.

Sumaiya A Islam¹, Alexandre A Lussier¹, Michael S Kobor²

¹Department of Medical Genetics, University of British Columbia, and Centre for Molecular Medicine and Therapeutics, BC Children's Hospital, Vancouver, BC, Canada.

Handbook of Clinical Neurology

|March 3, 2018

Summary

This summary is machine-generated.

Epigenomic profiling of postmortem human brain reveals insights into neural function and disease. Careful consideration of technical and biological factors is crucial for accurate epigenomic analysis in brain research.

Keywords:

DNA methylation epigenetics histone modifications human brain methodologies microRNA postmortem tissue

More Related Videos

Derivation of Leptomeninges Explant Cultures from Postmortem Human Brain Donors

Derivation of Leptomeninges Explant Cultures from Postmortem Human Brain Donors

Published on: January 21, 2017

Obtaining High Quality RNA from Single Cell Populations in Human Postmortem Brain Tissue

Obtaining High Quality RNA from Single Cell Populations in Human Postmortem Brain Tissue

Published on: August 6, 2009

Related Experiment Videos

Last Updated: Feb 13, 2026

Neuronal Nuclei Isolation from Human Postmortem Brain Tissue

Neuronal Nuclei Isolation from Human Postmortem Brain Tissue

Published on: October 1, 2008

Derivation of Leptomeninges Explant Cultures from Postmortem Human Brain Donors

Derivation of Leptomeninges Explant Cultures from Postmortem Human Brain Donors

Published on: January 21, 2017

Obtaining High Quality RNA from Single Cell Populations in Human Postmortem Brain Tissue

Obtaining High Quality RNA from Single Cell Populations in Human Postmortem Brain Tissue

Published on: August 6, 2009

Area of Science:

Neuroscience
Genetics
Molecular Biology

Background:

Epigenomic profiles in postmortem human brain tissue offer insights into neural function, plasticity, and neurobiology.
Disease-associated epigenetic alterations in the brain provide clues to pathogenesis and susceptibility.
Analyzing postmortem brain tissue requires careful consideration of technical and biological factors that can confound results.

Purpose of the Study:

To describe predominant forms of epigenetic regulation in the brain.
To discuss methodologies for assessing epigenetic marks.
To review existing epigenomic studies in human brain tissue and highlight challenges.

Main Methods:

DNA modification analysis
Chromatin structure assessment
Noncoding RNA expression profiling

Main Results:

Epigenomic mapping across diverse brain regions and developmental stages.
Identification of disease-associated epigenetic alterations.
Overview of established epigenomic studies in human brain samples.

Conclusions:

Epigenomic profiling is a powerful tool for understanding brain function and disease.
Methodologies for assessing DNA modifications, chromatin structure, and noncoding RNAs are essential.
Addressing technical and biological confounders is critical for reliable epigenomic analysis in postmortem brain research.