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High-resolution Structural Magnetic Resonance Imaging of the Human Subcortex In Vivo and Postmortem
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Postmortem magnetic resonance imaging.

Laura E Jonkman1, Jeroen J G Geurts1

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Summary
This summary is machine-generated.

Combining postmortem MRI and histopathology reveals the microscopic basis of MRI signal changes. This approach aids understanding of white and gray matter diseases like multiple sclerosis.

Keywords:
atrophygray matterhistopathologymagnetic resonance imagingmultiple sclerosispostmortemwhite matter

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Area of Science:

  • Neuroimaging
  • Neuropathology
  • Biomedical Engineering

Background:

  • Postmortem magnetic resonance imaging (MRI) and histopathology are crucial for understanding neurological diseases.
  • Integrating these techniques can bridge the gap between in vivo observations and tissue-level pathology.
  • Unexplained MRI signal changes necessitate detailed tissue-level investigation.

Purpose of the Study:

  • To provide an overview of studies combining postmortem MRI and histopathology.
  • To explain how this integrated approach elucidates the histologic basis of MRI signal alterations.
  • To highlight applications in neurological diseases, including multiple sclerosis.

Main Methods:

  • Establishing protocols to minimize postmortem delay for optimal tissue preservation.
  • Utilizing a range of conventional and advanced MRI sequences at various field strengths.
  • Employing diverse histopathologic techniques, including immunohistopathology for gray matter studies.

Main Results:

  • Demonstrated visualization of white matter pathology and repair mechanisms using advanced MRI.
  • Showcased historical and novel techniques for visualizing gray matter pathology.
  • Illustrated the utility of combined methods in studying multiple sclerosis and other neurological disorders.

Conclusions:

  • Combining postmortem MRI and histopathology effectively links imaging findings to tissue pathology.
  • This integrated approach is valuable for studying white and gray matter diseases.
  • Future research should focus on bridging in vivo and postmortem studies and including control tissues.