Related Experiment Video
Updated: Feb 13, 2026

Validated LC-MS/MS Panel for Quantifying 11 Drug-Resistant TB Medications in Small Hair Samples
Published on: May 19, 2020
Development and Validation of the Pediatric Medical Complexity Algorithm (PMCA) Version 3.0
Tamara D Simon1, Wren Haaland2, Katherine Hawley2
1Department of Pediatrics, University of Washington/Seattle Children's Hospital, Seattle, Wash; Seattle Children's Research Institute, Seattle, Wash.
The updated Pediatric Medical Complexity Algorithm (PMCA) version 3.0 accurately identifies children with complex chronic diseases (C-CD) using ICD-10-CM codes. This enhanced algorithm shows good sensitivity and specificity for classifying pediatric medical complexity.
Area of Science:
- Pediatric Health Services Research
- Medical Informatics
- Health Outcomes
Background:
- Classifying pediatric medical complexity is crucial for resource allocation and care management.
- Existing algorithms require updates to incorporate newer coding systems like ICD-10-CM.
- The Pediatric Medical Complexity Algorithm (PMCA) is a key tool for this classification.
Purpose of the Study:
- To modify the PMCA to include International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) codes.
- To assess the sensitivity and specificity of the new PMCA version 3.0 for classifying pediatric chronic disease (CD) levels.
- To evaluate the algorithm's performance in identifying children with complex chronic disease (C-CD).
Main Methods:
- PMCA version 2.0 was updated with ICD-10-CM codes to create version 3.0.
- The algorithm was applied to hospital discharge data for children with emergency department, day surgery, or inpatient encounters.
- A random sample of 300 children was reviewed to ascertain medical complexity levels and validate algorithm performance.
Main Results:
- PMCA version 3.0 demonstrated 86% sensitivity and 86% specificity for identifying complex chronic disease (C-CD).
- The algorithm achieved 65% sensitivity and 84% specificity for noncomplex chronic disease (NC-CD).
- For children without chronic disease, PMCA 3.0 showed 77% sensitivity and 93% specificity.
Conclusions:
- PMCA version 3.0 is a validated, publicly available algorithm for identifying children with C-CD.
- The updated algorithm exhibits strong sensitivity and specificity in classifying pediatric medical complexity using hospital discharge data.
- Performance is comparable to earlier PMCA versions, supporting its utility in clinical settings.
Related Concept Videos
Reliability and Validity
In Vitro Drug Release Testing: Overview, Development and Validation
Trial and Error and Algorithm
Inhaled Medications
Data Validation
Key parameters for method validation include:
Data Validation
Nursing assessment guides are generally based on holistic models rather than medical...

