Related Experiment Video
Updated: Feb 13, 2026

Validated LC-MS/MS Panel for Quantifying 11 Drug-Resistant TB Medications in Small Hair Samples
Published on: May 19, 2020
Development and Validation of the Pediatric Medical Complexity Algorithm (PMCA) Version 3.0
Tamara D Simon1, Wren Haaland2, Katherine Hawley2
1Department of Pediatrics, University of Washington/Seattle Children's Hospital, Seattle, Wash; Seattle Children's Research Institute, Seattle, Wash.
Insights
The updated Pediatric Medical Complexity Algorithm (PMCA) version 3.0 accurately identifies children with complex chronic diseases (C-CD) using ICD-10-CM codes. This enhanced algorithm shows good sensitivity and specificity for classifying pediatric medical complexity.
Area of Science:
- Pediatric Health Services Research
- Medical Informatics
- Health Outcomes
Background:
- Classifying pediatric medical complexity is crucial for resource allocation and care management.
- Existing algorithms require updates to incorporate newer coding systems like ICD-10-CM.
- The Pediatric Medical Complexity Algorithm (PMCA) is a key tool for this classification.
Purpose of the Study:
- To modify the PMCA to include International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) codes.
- To assess the sensitivity and specificity of the new PMCA version 3.0 for classifying pediatric chronic disease (CD) levels.
- To evaluate the algorithm's performance in identifying children with complex chronic disease (C-CD).
Main Methods:
- PMCA version 2.0 was updated with ICD-10-CM codes to create version 3.0.
- The algorithm was applied to hospital discharge data for children with emergency department, day surgery, or inpatient encounters.
- A random sample of 300 children was reviewed to ascertain medical complexity levels and validate algorithm performance.
Main Results:
- PMCA version 3.0 demonstrated 86% sensitivity and 86% specificity for identifying complex chronic disease (C-CD).
- The algorithm achieved 65% sensitivity and 84% specificity for noncomplex chronic disease (NC-CD).
- For children without chronic disease, PMCA 3.0 showed 77% sensitivity and 93% specificity.
Conclusions:
- PMCA version 3.0 is a validated, publicly available algorithm for identifying children with C-CD.
- The updated algorithm exhibits strong sensitivity and specificity in classifying pediatric medical complexity using hospital discharge data.
- Performance is comparable to earlier PMCA versions, supporting its utility in clinical settings.
Objective:
To modify the Pediatric Medical Complexity Algorithm (PMCA) to include both International Classification of Diseases, Ninth and Tenth Revisions, Clinical Modification (ICD-9/10-CM) codes for classifying children with chronic disease (CD) by level of medical complexity and to assess the sensitivity and specificity of the new PMCA version 3.0 for correctly identifying level of medical complexity.
Methods:
To create version 3.0, PMCA version 2.0 was modified to include ICD-10-CM codes. We applied PMCA version 3.0 to Seattle Children's Hospital data for children with ≥1 emergency department (ED), day surgery, and/or inpatient encounter from January 1, 2016, to June 30, 2017. Starting with the encounter date, up to 3 years of retrospective discharge data were used to classify children as having complex chronic disease (C-CD), noncomplex chronic disease (NC-CD), and no CD. We then selected a random sample of 300 children (100 per CD group). Blinded medical record review was conducted to ascertain the levels of medical complexity for these 300 children. The sensitivity and specificity of PMCA version 3.0 was assessed.
Results:
PMCA version 3.0 identified children with C-CD with 86% sensitivity and 86% specificity, children with NC-CD with 65% sensitivity and 84% specificity, and children without CD with 77% sensitivity and 93% specificity.
Conclusions:
PMCA version 3.0 is an updated publicly available algorithm that identifies children with C-CD, who have accessed tertiary hospital emergency department, day surgery, or inpatient care, with very good sensitivity and specificity when applied to hospital discharge data and with performance to earlier versions of PMCA.
Related Concept Videos
Reliability and Validity
In Vitro Drug Release Testing: Overview, Development and Validation
Trial and Error and Algorithm
Inhaled Medications
Data Validation
Key parameters for method validation include:
Data Validation
Nursing assessment guides are generally based on holistic models rather than medical...

