Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacogenetics and Pharmacogenomics: Overview01:29

Pharmacogenetics and Pharmacogenomics: Overview

3
Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...
3
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

3
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
3
Critical Region, Critical Values and Significance Level01:16

Critical Region, Critical Values and Significance Level

13.4K
The critical region, critical value, and significance level are interdependent concepts crucial in hypothesis testing.
In hypothesis testing, a sample statistic is converted to a test statistic using z, t, or chi-square distribution. A critical region is an area under the curve in  probability distributions demarcated by the critical value. When the test statistic falls in this region, it suggests that the null hypothesis must be rejected. As this region contains all those values of the...
13.4K
Critical Values01:31

Critical Values

10.4K
A critical value is a definite value obtained from a particular probability distribution at a predecided confidence level (or a predecided significance level) for a given population parameter. The critical value provides demarcation that separates the sample statistics that are likely to occur from the ones that are unlikely to occur based on the given probability distribution and the population parameter to be estimated. The critical value for normal distribution is obtained from the z...
10.4K
Critical Thinking01:19

Critical Thinking

1.2K
Critical thinking involves reflective and productive thinking and the evaluation of evidence. Critical thinkers seek to understand the deeper meaning of ideas, question assumptions, and make independent decisions about what to believe or do. Scientists, for instance, are often critical thinkers. Critical thinking also requires humility about what we know and don't know and the motivation to look beyond the obvious. It is essential for effective problem-solving.
Colleges and universities are...
1.2K
Critical Thinking I01:24

Critical Thinking I

5.3K
Critical thinking helps decision-making and allows nurses to recognize barriers to success and find solutions to possible issues. It helps to brainstorm and implement ideas to achieve goals. Critical thinking helps acknowledge and state workflow inefficiencies while improving management techniques. Nurses understand the value of critical thinking and look for fellow nurses with critical thinking skills to upgrade their professional standards. Critical thinking can advance a nurse's career...
5.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of variation in the α/β of cervical cancer on predicted clinical outcomes.

Journal of applied clinical medical physics·2026
Same author

The Impact of Recess on Chronic Stress Levels in Elementary School Children.

Children (Basel, Switzerland)·2025
Same author

In Vitro α/β Ratio Variations in Cervical Cancer, with Consequent Effects on Equivalent Dose in 2 Gy Fraction in High-Dose-Rate Brachytherapy.

Advances in radiation oncology·2025
Same author

Magnetic Resonance Imaging of Macrophage Response to Radiation Therapy.

Cancers·2023
Same author

Effects of Interfraction Dose Variations of Target and Organs at Risk on Clinical Outcomes in High Dose Rate Brachytherapy for Cervical Cancer.

Cancers·2023
Same author

Statistical Analysis of Interfraction Dose Variations of High-Risk Clinical Target Volume and Organs at Risk for Cervical Cancer High-Dose-Rate Brachytherapy.

Advances in radiation oncology·2022

Related Experiment Video

Updated: Feb 13, 2026

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies
10:38

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies

Published on: January 16, 2019

20.9K

Pharmacogenomics in Critical Care.

Dennis Cheek1, Lynnette Howington1

  • 1Dennis Cheek is Abell-Hanger Professor of Gerontological Nursing, Texas Christian University, Harris College of Nursing and Health Sciences, 2800 West Bowie Street, Bass Building Room 2232, Fort Worth, TX 76129 (d.cheek@tcu.edu). Lynnette Howington is Assistant Professor of Professional Practice, Texas Christian University, Harris College of Nursing and Health Sciences, Fort Worth, Texas.

AACN Advanced Critical Care
|March 3, 2018
PubMed
Summary

Pharmacogenomics research, focusing on the cytochrome P450 system, impacts drug effectiveness. Understanding these genetic variations is crucial for critical care nurses managing patient medications.

Keywords:
critical caregeneticsgenomicsnursingpersonalized medicinepharmacogenomicsprecision medicine

More Related Videos

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care
14:28

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care

Published on: May 10, 2024

2.3K
Endotoxin Activity Assay for the Detection of Whole Blood Endotoxemia in Critically Ill Patients
06:28

Endotoxin Activity Assay for the Detection of Whole Blood Endotoxemia in Critically Ill Patients

Published on: June 24, 2019

9.9K

Related Experiment Videos

Last Updated: Feb 13, 2026

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies
10:38

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies

Published on: January 16, 2019

20.9K
Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care
14:28

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care

Published on: May 10, 2024

2.3K
Endotoxin Activity Assay for the Detection of Whole Blood Endotoxemia in Critically Ill Patients
06:28

Endotoxin Activity Assay for the Detection of Whole Blood Endotoxemia in Critically Ill Patients

Published on: June 24, 2019

9.9K

Area of Science:

  • Genomic research and molecular pathophysiology.
  • Pharmacogenomics and drug metabolism.
  • Clinical pharmacology in critical care.

Background:

  • Post-Human Genome Project research elucidates molecular pathophysiology.
  • Cytochrome P450 system's role in drug pharmacokinetics and pharmacodynamics is increasingly recognized.
  • Understanding genetic influences on drug response is vital for personalized medicine.

Purpose of the Study:

  • To discuss pharmacogenomics and the cytochrome P450 system's function in drug metabolism.
  • To examine drugs used in critical care settings.
  • To highlight the clinical significance for bedside critical care nurses.

Main Methods:

  • Review of scientific literature on pharmacogenomics.
  • Analysis of the cytochrome P450 enzyme system's role in drug metabolism.
  • Focus on drugs relevant to critical care environments.

Main Results:

  • Genomic variations significantly affect drug pharmacodynamics and pharmacokinetics.
  • The cytochrome P450 system is a key determinant of drug metabolism.
  • Specific drug examples relevant to critical care are identified.

Conclusions:

  • Pharmacogenomics offers insights into individual drug responses.
  • The cytochrome P450 system is central to understanding drug interactions and efficacy.
  • Critical care nurses require pharmacogenomic knowledge for optimal patient management.