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Related Concept Videos

Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Lung Capacity01:47

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The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
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Genomic Imprinting and Inheritance02:30

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
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Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

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While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
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Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes02:16

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The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...
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Pleura of the Lungs01:13

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The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...
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Updated: Feb 13, 2026

Generation of Human 3D Lung Tissue Cultures 3D-LTCs for Disease Modeling
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Generation of Human 3D Lung Tissue Cultures 3D-LTCs for Disease Modeling

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Lung Disease and Genomics.

Kenneth Wysocki1

  • 1Kenneth Wysocki is a Family Nurse Practitioner, Phoenix, AZ (doctorken@kenwysocki.com).

AACN Advanced Critical Care
|March 3, 2018
PubMed
Summary
This summary is machine-generated.

Genomic medicine advances lung disease treatment by tailoring therapies to individual patients. Precision medicine, using genetic insights, is revolutionizing care for lung cancer, cystic fibrosis, asthma, and COPD.

Keywords:
COPDasthmacystic fibrosisgenomiclung cancer

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Area of Science:

  • Genomic medicine and its application in respiratory diseases.

Background:

  • Genomic medicine has significantly advanced understanding of lung diseases like cystic fibrosis and lung cancer.
  • Asthma and chronic obstructive pulmonary disease (COPD) present greater complexity due to heterogeneous pathogenesis and expression, challenging traditional treatment approaches.

Purpose of the Study:

  • To review the evolving landscape of precision medicine in major lung diseases: lung cancer, COPD, asthma, and cystic fibrosis.
  • To highlight the growing knowledge in pharmacogenomics, clinical guidelines, genome editing, and genomic health for respiratory conditions.

Main Methods:

  • Literature review focusing on genomic medicine applications in lung diseases.
  • Analysis of research trends in precision medicine for specific lung conditions.

Main Results:

  • Specific genotypes are key to precision medicine for lung cancer and cystic fibrosis.
  • Precision medicine approaches for asthma and COPD are developing due to disease complexity.

Conclusions:

  • Growing knowledge in genomics, pharmacogenomics, and genome editing will guide future clinical treatment options for lung diseases.
  • Genomic health strategies aim to reduce risk and promote better health outcomes in patients with lung conditions.