Related Experiment Video

Updated: Feb 13, 2026

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
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Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers

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HER2 Deregulation in Lung Cancer: Right Time to Adopt an Orphan?

Federico Cappuzzo1, Lorenza Landi2

  • 1Medical Oncology Department, AUSL della Romagna, Ravenna, Italy. federico.cappuzzo@auslromagna.it.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|March 3, 2018
PubMed

Insights

HER2-deregulated non-small cell lung cancer lacks targeted therapies. Osimertinib shows promise as a potential treatment for HER2-amplified or mutated lung cancer, alone or in combination.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • HER2-deregulated non-small cell lung cancer (NSCLC) currently lacks specific therapies due to challenges in patient selection and drug development.
  • HER2 alterations are found in a subset of NSCLC patients, representing an unmet therapeutic need.

Purpose of the Study:

  • To explore the potential efficacy of osimertinib in treating HER2-altered NSCLC.
  • To evaluate osimertinib as a single agent or in combination therapy for HER2-driven lung cancer.

Main Methods:

  • Review of recent evidence and clinical data regarding osimertinib activity in HER2-altered NSCLC.
  • Analysis of potential patient selection strategies for HER2-targeted therapies.

Main Results:

  • Emerging evidence suggests osimertinib may be effective in HER2-amplified or mutated NSCLC.
  • Osimertinib demonstrates potential as both a monotherapy and a combination treatment option.

Conclusions:

  • Osimertinib represents a promising therapeutic avenue for patients with HER2-deregulated NSCLC.
  • Further research is warranted to optimize patient selection and treatment strategies involving osimertinib for HER2-altered lung cancer.

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