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Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
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Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

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Atypical chemokine receptor CCRL2 is overexpressed in prostate cancer cells

Niradiz Reyes1,2, Ines Benedetti1,3, Juan Rebollo1,4

  • 1Department of Basic Sciences, School of Medicine, University of Cartagena, Cartagena, Colombia.

Journal of Biomedical Research
|March 3, 2018
PubMed

Insights

Atypical chemokine receptor 5 (ACKR5/CCRL2) is overexpressed in prostate cancer. This finding suggests ACKR5/CCRL2 may play a role in prostate tumorigenesis and offers a potential therapeutic target.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Atypical chemokine receptors (ACKRs) modulate chemokine availability and function, influencing pathophysiological processes like tumorigenesis.
  • The ACKR family includes five members: ACKR1/DARC, ACKR2/D6, ACKR3/CXCR7, ACKR4/CCRL1, and ACKR5/CCRL2.
  • The role and expression of ACKR5/CCRL2 in prostate cancer have not been previously investigated.

Purpose of the Study:

  • To investigate the differential expression of atypical chemokine receptors in prostate cancer.
  • To specifically evaluate the expression and potential role of ACKR5/CCRL2 in prostate cancer development and progression.

Main Methods:

  • Quantitative PCR was employed to assess the differential expression of all five ACKR family members in prostate cancer.
  • Protein level analysis of ACKR5/CCRL2 was conducted in a metastatic prostate cancer cell line and patient-derived malignant tissues.

Main Results:

  • Differential expression patterns of atypical chemokine receptors were observed in prostate cancer.
  • ACKR5/CCRL2 was confirmed to be overexpressed at the protein level in a metastatic prostate cancer cell line.
  • Elevated ACKR5/CCRL2 protein levels were also detected in malignant prostatic tissues from prostate cancer patients.

Conclusions:

  • ACKR5/CCRL2 is overexpressed in prostate cancer, indicating its potential involvement in the disease.
  • These findings highlight ACKR5/CCRL2 as a potential biomarker or therapeutic target for prostate cancer.

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