Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

1.2K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.2K
Second Order systems II01:18

Second Order systems II

414
In an underdamped second-order system, where the damping ratio ζ is between 0 and 1, a unit-step input results in a transfer function that, when transformed using the inverse Laplace method, reveals the output response. The output exhibits a damped sinusoidal oscillation, and the difference between the input and output is termed the error signal. This error signal also demonstrates damped oscillatory behavior. Eventually, as the system reaches a steady state, the error diminishes to zero.
414
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

6.2K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.2K
First Order Systems01:21

First Order Systems

435
First-order systems, such as RC circuits, are foundational in understanding dynamic systems due to their straightforward input-output relationship. Analyzing their responses to different input functions under zero initial conditions reveals significant insights into system behavior.
When a first-order system is subjected to a unit-step input, its response is characterized by its transfer function. By applying the Laplace transform of the unit-step input to the transfer function, expanding the...
435
Second Order systems I01:20

Second Order systems I

619
A servo system exemplifies a second-order system, featuring a proportional controller and load elements that ensure the output position aligns with the input position. The relationship between these components is described by a second-order differential equation. Applying the Laplace transform under zero initial conditions yields the transfer function, showing how inputs are converted to outputs in the system.
By reinterpreting the system, one can derive the closed-loop transfer function, which...
619
Thermodynamic Systems01:06

Thermodynamic Systems

8.3K
A thermodynamic system is a set of objects whose thermodynamic properties are of interest. The system is considered to be embedded in its surroundings or the environment. The system and its environment can exchange heat and do work on each other through a boundary that separates them. However, the immediate surroundings of the system interact with it directly and therefore have a much stronger influence on its behavior and properties.
Consider an example of  tea boiling in a kettle. The...
8.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genome-wide Association Study Identifies 2 New Loci Associated With Anti-NMDAR Encephalitis.

Neurology(R) neuroimmunology & neuroinflammation·2021
Same author

Microbial Diversity and Abundance of <i>Parabacteroides</i> Mediate the Associations Between Higher Intake of Flavonoid-Rich Foods and Lower Blood Pressure.

Hypertension (Dallas, Tex. : 1979)·2021
Same author

Sex-specific genetic factors affect the risk of early-onset periodontitis in Europeans.

Journal of clinical periodontology·2021
Same author

Immunopeptidomics toolkit library (IPTK): a python-based modular toolbox for analyzing immunopeptidomics data.

BMC bioinformatics·2021
Same author

A survey of functional dyspepsia in 361,360 individuals: Phenotypic and genetic cross-disease analyses.

Neurogastroenterology and motility·2021
Same author

Genetic association and differential expression of HLAComplexGroup lncRNAs in pemphigus.

Journal of autoimmunity·2021
Same journal

In-depth multimodal validation of <sup>18</sup>F-THK5351 for imaging monoamine oxidase-B-mediated reactive astrogliosis in Alzheimer's and related neurodegenerative diseases.

Experimental & molecular medicine·2026
Same journal

Exercise-stimulated primary cilia on preosteoclasts promote periosteal-bone formation.

Experimental & molecular medicine·2026
Same journal

Therapeutic effect of intranasal nicotinamide adenine dinucleotide in the restoration of olfactory dysfunction.

Experimental & molecular medicine·2026
Same journal

Metabolic reprogramming of myeloid cells in cancer: from lactate-NAMPT axis to AI-guided therapeutics.

Experimental & molecular medicine·2026
Same journal

Coordinated DNA 5-mC and RNA m<sup>5</sup>C methylation epigenetically regulates MZF1 splice variants to drive EGFR-TKI resistance.

Experimental & molecular medicine·2026
Same journal

Metastasis-related genomic aberrations and evolutionary trajectory in uveal melanoma.

Experimental & molecular medicine·2026
See all related articles

Related Experiment Video

Updated: Feb 13, 2026

Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis
06:05

Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis

Published on: January 27, 2023

28.5K

Whither systems medicine?

Rolf Apweiler1, Tim Beissbarth2, Michael R Berthold3

  • 1European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK.

Experimental & Molecular Medicine
|March 3, 2018
PubMed
Summary
This summary is machine-generated.

Systems medicine integrates diverse expertise to leverage medical data for patient benefit. This interdisciplinary approach offers new knowledge extraction and improved healthcare through advanced data analysis.

More Related Videos

Author Spotlight: Establishing a Rodent Model for Investigating Depression Factors in Traditional Mongolian Medicine
05:56

Author Spotlight: Establishing a Rodent Model for Investigating Depression Factors in Traditional Mongolian Medicine

Published on: October 27, 2023

1.8K
Localized RNAi and Ectopic Gene Expression in the Medicinal Leech
16:19

Localized RNAi and Ectopic Gene Expression in the Medicinal Leech

Published on: April 17, 2008

10.1K

Related Experiment Videos

Last Updated: Feb 13, 2026

Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis
06:05

Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis

Published on: January 27, 2023

28.5K
Author Spotlight: Establishing a Rodent Model for Investigating Depression Factors in Traditional Mongolian Medicine
05:56

Author Spotlight: Establishing a Rodent Model for Investigating Depression Factors in Traditional Mongolian Medicine

Published on: October 27, 2023

1.8K
Localized RNAi and Ectopic Gene Expression in the Medicinal Leech
16:19

Localized RNAi and Ectopic Gene Expression in the Medicinal Leech

Published on: April 17, 2008

10.1K

Area of Science:

  • Medicine
  • Biomedical Informatics
  • Translational Research

Background:

  • Rapid advancements in medical data generation, storage, and retrieval are transforming healthcare and research.
  • The increasing volume and complexity of data necessitate novel analytical approaches.

Purpose of the Study:

  • To critically assess the opportunities and challenges of systems approaches in medicine.
  • To define systems medicine and its role in modern healthcare and research.

Main Methods:

  • Interdisciplinary collaboration involving physicians, researchers, and experts in biology, biostatistics, informatics, mathematics, and computational modeling.
  • Analysis of current developments in medicine, healthcare, and research needs.
  • Critical assessment of systems approaches.

Main Results:

  • Systems medicine emerges as a crucial interdisciplinary framework.
  • It enables informed data acquisition and analysis for knowledge extraction.
  • Opportunities include enhanced patient benefit through data-driven insights.

Conclusions:

  • Systems medicine is a multilevel, multidisciplinary methodological framework.
  • It is essential for extracting previously inaccessible knowledge from complex medical data.
  • Its application promises significant benefits for patients and the healthcare system.