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Vitamin D and vitamin D receptor levels in children with attention-deficit/hyperactivity disorder

Nilfer Sahin1, Hatice Altun2, Ergül Belge Kurutas3

  • 1Department of Child and Adolescent Psychiatry, Muğla Sıtkı Koçman University, Muğla, Turkey.

Neuropsychiatric Disease and Treatment
|March 3, 2018
PubMed

Insights

Children with attention-deficit/hyperactivity disorder (ADHD) show lower vitamin D and vitamin D receptor levels. This is the first study to examine vitamin D receptor levels in ADHD patients.

Area of Science:

  • Pediatric Neurology
  • Endocrinology
  • Nutritional Science

Background:

  • Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder.
  • Vitamin D plays a crucial role in various bodily functions, including brain development and neurotransmitter regulation.
  • Vitamin D deficiency has been anecdotally linked to neurological conditions, but specific receptor level data in ADHD is lacking.

Purpose of the Study:

  • To investigate serum levels of vitamin D and its receptor in children diagnosed with ADHD.
  • To compare these levels against a control group of healthy children.
  • To explore potential correlations between vitamin D status and ADHD.

Main Methods:

  • A cross-sectional study involving 80 children (40 with ADHD, 40 controls), aged 6-12 years.
  • Serum samples were analyzed for vitamin D, vitamin D receptor, calcium, phosphorus, and alkaline phosphatase.
  • Vitamin D receptor levels were quantified using the quantitative sandwich enzyme immunoassay technique.

Main Results:

  • Children with ADHD exhibited significantly lower serum levels of vitamin D and vitamin D receptor compared to controls.
  • No significant differences were observed in serum calcium, phosphorus, or alkaline phosphatase levels between groups.
  • ADHD subtypes did not show significant variations in the measured vitamin D-related parameters.

Conclusions:

  • The findings suggest a potential association between reduced vitamin D and vitamin D receptor levels and ADHD in children.
  • This study is the first to report on vitamin D receptor levels specifically within the context of ADHD.
  • Further research is warranted to explore the therapeutic implications of vitamin D supplementation in managing ADHD.
Abstract

Keywords:
attention-deficit/hyperactivity disordervitamin Dvitamin D receptor

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