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A physiologically based model for denitrogenation kinetics
Ira Katz1,2, Jacqueline Murdock1, Marc Palgen1
1Medical R&D, Air Liquide Santé International, Centre de Recherche Claude-Delorme, Jouy-en-Josas, France.
Medical Gas Research
|March 3, 2018
Summary
This study applies a pharmacokinetic model to estimate nitrogen (N₂) removal time during oxygen breathing. The model aligns with experimental data, aiding surgical planning by predicting denitrogenation kinetics.
Area of Science:
- Physiology
- Pharmacokinetics
- Medical Gas Administration
Background:
- The body is normally saturated with nitrogen (N₂) from ambient air.
- Medical gas administration requires lower N₂ concentrations, initiating N₂ release from tissues.
Purpose of the Study:
- To apply a physiologically based pharmacokinetic model for denitrogenation kinetics.
- To estimate the time required for nitrogen removal in clinical settings, particularly for surgical procedures.
Main Methods:
- Utilized a physiologically based pharmacokinetic model to simulate denitrogenation.
- Compared model predictions with published experimental data on end-tidal N₂ concentrations during 100% oxygen breathing.
Main Results:
- The pharmacokinetic model demonstrated general agreement with experimental data.
- Identified correlations between denitrogenation time and subject weight.
Conclusions:
- The developed model provides a reliable method for estimating denitrogenation time.
- This model can assist in planning surgical procedures involving high concentrations of medical gases.
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