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Updated: Feb 13, 2026

Author Spotlight: Generation of Patient-Derived Podocytes from Skin Biopsies
Published on: May 26, 2023
Non-muscle myosins and the podocyte
Marina Noris1, Giuseppe Remuzzi2,3
1Mario Negri Institute for Pharmacological Research, Clinical Research Center for Rare Diseases "Aldo e Cele Daccò", Department of Molecular Medicine, Ranica, Italy.
Abstract:
Proteinuria is often accompanied by a pathological change in the glomerulus that is refereed as effacement of the podocyte foot processes. The highly dynamic podocyte foot processes contain an actin-based contractile apparatus comparable to that of pericytes, which needs to be precisely and temporally controlled to withstand high pressure in the capillaries and to maintain intact glomerular filtration properties. This review outlines the most recent concepts on the function of the podocyte contractile apparatus with a focus on the role of non-muscle myosins as they have been highlighted by studies in monogenic hereditary proteinuric diseases.
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