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Updated: Feb 13, 2026

A Porcine Model of Acute Autologous Pulmonary Embolism
Published on: September 6, 2024
Case of intersurgical acute massive pulmonary embolism with successful thrombolysis therapy
I V Kostetskiy1, M V Agalakov2, V V Tukhanov3
1Department of Anesthesiology and Intensive Care No. 1, City Hospital No. 23, Yekaterinburg, Russia.
Abstract:
A 56-year-old man underwent surgery to repair an open left tibial fracture. At the end of the surgery, he exhibited haemodynamic instability requiring an increased epinephrine dose. The situation was life-threatening, and the patient was at risk for pulmonary thromboembolism. Although surgery is a contraindication to thrombolysis, we performed intravenous thrombolysis with alteplase and used a femoral tourniquet to decrease blood loss. Once the patient was haemodynamically stable, he was taken to the intensive care unit. The patient recovered and was discharged with a long-term anticoagulation plan. In conclusion, thrombolysis can successfully treat life-threatening pulmonary thromboembolism during the early postoperative period.
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