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Updated: Feb 13, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Cardiovascular Imaging Techniques in Systemic Rheumatic Diseases
Fabiola Atzeni1, Marco Corda2, Luigi Gianturco3
1Rheumatology Unit, University of Messina, Messina, Italy.
Insights
Patients with systemic rheumatic diseases face higher cardiovascular risks. Advanced imaging techniques like speckle tracking echocardiography and 3D US offer more accurate diagnoses for cardiovascular involvement.
Area of Science:
- Cardiology
- Rheumatology
- Medical Imaging
Background:
- Patients with systemic rheumatic diseases exhibit a significantly elevated risk of cardiovascular (CV) events and mortality compared to the general population.
- Cardiovascular involvement in these patients is diverse, affecting multiple heart structures, but early diagnosis and prompt treatment are now feasible.
Purpose of the Study:
- To review current and emerging diagnostic methods for evaluating cardiovascular involvement in patients with systemic rheumatic diseases.
- To highlight the diagnostic accuracy of newer imaging modalities.
Main Methods:
- Transthoracic/transesophageal echocardiography, MRI, and CT for valve abnormalities, pericardial disease, and ventricular function.
- Coronary artery diameter assessment via quantitative coronarography or intravascular ultrasound.
- Coronary flow reserve and peripheral circulation evaluation using various non-invasive and invasive imaging and measurement techniques, including ultrasonography (US), MRI, CT, PET, and strain-gauge plethysmography.
Main Results:
- Established imaging techniques reliably detect CV involvement in rheumatic diseases.
- Speckle tracking echocardiography and 3-dimensional US represent recent advancements offering superior diagnostic accuracy.
Conclusions:
- Comprehensive cardiovascular risk assessment is crucial for patients with systemic rheumatic diseases.
- Emerging technologies like speckle tracking echocardiography and 3D US enhance the early and accurate diagnosis of cardiovascular complications in this patient group.
Abstract:
The risk of cardiovascular (CV) events and mortality is significantly higher in patients with systemic rheumatic diseases than in the general population. Although CV involvement in such patients is highly heterogeneous and may affect various structures of the heart, it can now be diagnosed earlier and promptly treated. Various types of assessments are employed for the evaluation of CV risk such as transthoracic or transesophageal echocardiography, magnetic resonance imaging (MRI), and computed tomography (CT) to investigate valve abnormalities, pericardial disease, and ventricular wall motion defects. The diameter of coronary arteries can be assessed using invasive quantitative coronarography or intravascular ultrasound, and coronary flow reserve can be assessed using non-invasive transesophageal or transthoracic ultrasonography (US), MRI, CT, or positron emission tomography (PET) after endothelium-dependent vasodilation. Finally, peripheral circulation can be measured invasively using strain-gauge plethysmography in an arm after the arterial infusion of an endothelium-dependent vasodilator or non-invasively by means of US or MRI measurements of flow-mediated vasodilation of the brachial artery. All of the above are reliable methods of investigating CV involvement, but more recently, introduced use of speckle tracking echocardiography and 3-dimensional US are diagnostically more accurate.
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