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Updated: Feb 13, 2026
05:17
Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
Published on: April 18, 2025
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[18F] AV-1451 uptake in corticobasal syndrome: the influence of beta-amyloid and clinical presentation
F Ali1, J L Whitwell2, P R Martin3
1Department of Neurology, Mayo Clinic, 200 1st St SW, Rochester, MN, 55905, USA. ali.farwa@mayo.edu.
Journal of Neurology
|March 3, 2018
Summary
Molecular neuroimaging with [18F] AV-1451 PET in corticobasal syndrome (CBS) shows variable tau uptake patterns. Uptake depends on beta-amyloid status and clinical presentation, such as apraxia of speech (AOS).
Area of Science:
- Neuroimaging
- Neuropathology
- Nuclear Medicine
Background:
- Corticobasal syndrome (CBS) presents with diverse underlying pathologies, making accurate diagnosis challenging.
- Predicting the specific pathology in CBS is often unreliable.
- Molecular neuroimaging offers a potential tool for improved pathological assessment in CBS.
Purpose of the Study:
- To investigate regional [18F] AV-1451 positron emission tomography (PET) uptake patterns in patients with CBS.
- To determine if [18F] AV-1451 uptake patterns differ based on beta-amyloid (Aβ) deposition status.
- To explore variations in [18F] AV-1451 uptake related to distinct clinical presentations, specifically comparing typical CBS with apraxia of speech (AOS).
Main Methods:
- Fourteen patients meeting CBS criteria underwent both Pittsburgh Compound B (PiB) PET and [18F] AV-1451 PET scans.
- Patients were categorized as PiB-positive (PiB+) or PiB-negative (PiB-) based on global PiB uptake.
- Standardized uptake value ratios (SUVRs) for [18F] AV-1451 were calculated in 14 regions of interest and compared to a control group.
Main Results:
- 43% of CBS patients were PiB+; three showed widespread cortical [18F] AV-1451 uptake.
- In PiB-negative CBS patients, elevated [18F] AV-1451 uptake in specific motor regions was observed only in those with a history of AOS.
- PiB-negative CBS patients without AOS did not exhibit elevated [18F] AV-1451 uptake in any region compared to controls.
Conclusions:
- Regional [18F] AV-1451 uptake in CBS is variable and influenced by both beta-amyloid presence and clinical phenotype, including AOS.
- PiB-positive CBS does not definitively confirm Alzheimer's disease but warrants monitoring for potential evolution.
- Molecular imaging patterns can provide insights into the heterogeneity of CBS pathologies.
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