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Published on: October 17, 2018
Autonomic symptoms following Zika virus infection
Yhojan Rodríguez1, Manuel Rojas1, Carolina Ramírez-Santana1
1Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Carrera 26-63-B-51, 110010, Bogotá, Colombia.
Purpose:
To determine if autonomic symptoms are associated with previous Zika virus infection.
Methods:
Case-control study including 35 patients with Zika virus infection without evidence of neurological disease and 105 controls. Symptoms of autonomic dysfunction were assessed with the composite autonomic symptom scale 31 (COMPASS-31).
Results:
Patients with previous Zika virus infection had significantly higher COMPASS-31 score than controls regardless of age and sex (p = 0.007). The main drivers for the higher scores where orthostatic intolerance (p = 0.003), secretomotor (p = 0.04) and bladder symptoms (p < 0.001).
Conclusion:
Zika virus infection is associated with autonomic dysfunction. The mechanisms remain to be elucidated.
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