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Expression of IL-33 in chronic lesional skin of canine atopic dermatitis
Ryota Asahina1, Hidetaka Nishida1, Hiroaki Kamishina1
1Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.
Background:
In humans, interleukin (IL)-33 plays a critical role in the enhancement of allergic skin inflammation. However, it currently remains unclear whether IL-33 is involved in the pathogenesis of canine atopic dermatitis (cAD).
Objectives:
To examine the expression of IL-33 in chronic lesional skin of cAD.
Animals:
Eight dogs with spontaneous cAD and five healthy dogs were used.
Methods:
The transcription of il-33 in chronic lesional skin of cAD was quantified by quantitative reverse transcription PCR. The expression of IL-33 was evaluated immunohistochemically using an anti-human IL-33 monoclonal antibody with cross-reactivity to canine IL-33.
Results:
The transcription levels of il-33 in chronic lesional skin of cAD were significantly higher than those in normal skin of healthy dogs. Keratinocytes were a major cellular source of IL-33 production in chronic lesional skin of cAD.
Conclusions And Clinical Importance:
The results indicate that IL-33 is involved in chronic lesional skin of cAD.
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