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Related Concept Videos

Constant Volume Calorimetry02:41

Constant Volume Calorimetry

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Calorimeters are useful to determine the heat released or absorbed by a chemical reaction. Coffee cup calorimeters are designed to operate at constant (atmospheric) pressure and are convenient to measure heat flow (or enthalpy change) accompanying processes that occur in solution at constant pressure. A different type of calorimeter that operates at constant volume, colloquially known as a bomb calorimeter, is used to measure the energy produced by reactions that yield large amounts of heat and...
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Volume of Distribution01:20

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The apparent volume of distribution (Vd) is a crucial pharmacokinetic parameter representing the hypothetical body fluid volume into which a drug disperses. It is calculated based on the total amount of drug in the body (estimated from the administered dose and bioavailability) divided by the plasma drug concentration. The total amount of drug in the body does not directly refer to the dose given but is derived by accounting for absorption, distribution, metabolism, and excretion processes.
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Problem Solving: Volume01:13

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The volume of a fuel tank mounted on the wing of a jet aircraft can be modeled using the concept of solids of revolution. In this case, the tank is formed by rotating a two-dimensional region, defined by a mathematical function, about the x-axis. The region extends along the axis from zero to two meters, and the resulting three-dimensional shape is symmetric about the axis of rotation. Because the boundary curve lies directly against the axis, the disk method is an appropriate technique for...
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Respiratory volumes are crucial metrics, meticulously measured to quantify the air exchanged in and out of the lungs during various phases of the breathing cycle. These precise measurements are vital for assessing lung function, diagnosing respiratory conditions, and monitoring overall respiratory health. Each parameter provides specific insights into the mechanics of breathing and the functional capacity of the lungs.
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In mechanics, work is done on an object when the force acting on it displaces the object. In thermodynamics, work done on a system can be estimated when the system's volume changes during any thermodynamic process.
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Population Growth00:57

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Population size is dynamic, increasing with birth rates and immigration, and decreasing with death rates and emigration. In ideal conditions with unlimited resources, populations can increase exponentially, which plots as a J-shaped growth rate curve of population size against time. This type of curve is characteristic of newly-introduced invasive species, or populations that have suffered catastrophic declines and are rebounding.
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Related Experiment Video

Updated: Feb 13, 2026

In Situ Visualization of Axon Growth and Growth Cone Dynamics in Acute Ex Vivo Embryonic Brain Slice Cultures
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Normative human brain volume growth.

Mallory Peterson1,2, Benjamin C Warf3, Steven J Schiff1,4

  • 11The Center for Neural Engineering and.

Journal of Neurosurgery. Pediatrics
|March 3, 2018
PubMed
Summary

Researchers identified the Weibull model as the best fit for normative human brain volume growth, enabling the creation of clinical growth charts for conditions like hydrocephalus.

Keywords:
WeibullWest ontogenicallometrichydrocephaluspower lawvolumetric

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Area of Science:

  • Neuroscience
  • Biostatistics
  • Pediatrics

Background:

  • Accurate models for human brain volume growth are lacking.
  • Clinical tools are needed for managing conditions like hydrocephalus.

Purpose of the Study:

  • To identify the best statistical model for normative human brain volume growth.
  • To develop clinically applicable growth charts.

Main Methods:

  • Compared Weibull, two-term power law, West ontogenic, and Gompertz models.
  • Used nonlinear least squares regression on NIH MRI repository data.
  • Developed prediction bound curves for percentile estimates.

Main Results:

  • The Weibull model demonstrated the best statistical fit for both male and female brain volume growth.
  • The two-term power law model yielded the poorest results.
  • Reproducible statistical measures and goodness-of-fit parameters were provided.

Conclusions:

  • The Weibull model is the most effective for normative brain volume growth curves.
  • Developed growth charts can aid clinical studies and hydrocephalus management.
  • Further research with diverse populations is needed for improved predictive models.