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Aberrant functional network connectivity in psychopathy from a large (N = 985) forensic sample.
Flor A Espinoza1, Victor M Vergara1, Daisy Reyes1,2
1The Mind Research Network, Albuquerque, New Mexico, 87106.
Human Brain Mapping
|March 3, 2018
Summary
Psychopathy
Area of Science:
- Neuroscience
- Psychiatry
- Psychology
Background:
- Psychopathy is a personality disorder linked to crime.
- Previous research focused on specific brain regions.
- Understanding neural correlates aids early assessment and treatment.
Purpose of the Study:
- To investigate whole-brain functional connectivity in psychopathy.
- To associate functional network connectivity (FNC) with psychopathic traits.
- To explore neural underpinnings of psychopathy's affective/interpersonal symptoms.
Main Methods:
- Used resting-state functional magnetic resonance imaging (fMRI) on 985 incarcerated males.
- Applied group-independent component and regression analyses.
- Examined functional connectivity between resting-state networks (RSNs) and psychopathy scores.
Main Results:
- Factor 1 (interpersonal/affective) scores correlated with altered FNC in seven brain domains.
- Paralimbic regions (insula, cingulate cortex, amygdala, OFC, STG) showed significant FNC associations with Factor 1.
- No significant FNC associations were found for Factor 2 or total psychopathy scores.
Conclusions:
- Aberrant functional connectivity in multiple brain networks, including paralimbic areas, underlies psychopathy's affective and interpersonal symptoms.
- Whole-brain analysis reveals network-level alterations in psychopathy.
- Findings may inform early detection and therapeutic strategies for psychopathy.
Keywords:
functional network connectivitygroup independent component analysismale inmatespsychopathyresting-state fMRIMore Related Videos
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