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Nrf2-Keap1 signaling in oxidative and reductive stress

Ilaria Bellezza1, Ileana Giambanco1, Alba Minelli1

  • 1Department of Experimental Medicine, University of Perugia, Piazza Lucio Severi 1, 06132 Perugia, Italy.

Biochimica Et Biophysica Acta. Molecular Cell Research
|March 3, 2018
PubMed
Summary

The Nrf2-Keap1 system is a cellular defense against oxidative stress. This review explores its functions, particularly in striated muscle, and its role in oxidative and reductive stress.

Keywords:
Antioxidant systemAutophagyNrf2/Keap1Nrf2/NF-κB cross-talkOxidative stressReductive stressStriated muscle

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