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A comparative in silico linear B-cell epitope prediction and characterization for South American and African

Rafael Lucas Muniz Guedes1, Carla Monadeli Filgueira Rodrigues2, Nicolas Coatnoan3

  • 1Laboratório Nacional de Computação Científica (LNCC), Av. Getúlio Vargas, 333, Petrópolis, RJ, Brazil; Grupo Hermes Pardini, Setor de Pesquisa e Desenvolvimento, Vespasiano, MG, Brazil.

Genomics
|March 3, 2018
PubMed

Trypanosoma vivax is a parasite widespread across Africa and South America. Immunological methods using recombinant antigens have been developed aiming at specific and sensitive detection of infections caused by T. vivax. Here, we sequenced for the first time the transcriptome of a virulent T. vivax strain (Lins), isolated from an outbreak of severe disease in South America (Brazil) and performed a computational integrated analysis of genome, transcriptome and in silico predictions to identify and characterize putative linear B-cell epitopes from African and South American T. vivax. A total of 2278, 3936 and 4062 linear B-cell epitopes were respectively characterized for the transcriptomes of T. vivax LIEM-176 (Venezuela), T. vivax IL1392 (Nigeria) and T. vivax Lins (Brazil) and 4684 for the genome of T. vivax Y486 (Nigeria). The results presented are a valuable theoretical source that may pave the way for highly sensitive and specific diagnostic tools.

Keywords:
BioinformaticsBloodstream formsLinear B-cell epitopesTranscriptomicsTrypanosoma vivax

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