Related Experiment Video
Updated: Feb 13, 2026

Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish
Published on: February 22, 2019
Increased risk of hematologic malignancies in primary immunodeficiency disorders: opportunities for immunotherapy
Dorit Verhoeven1, Arie Jan Stoppelenburg1, Friederike Meyer-Wentrup2
1Department of Pediatrics and Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Abstract:
Primary immunodeficiency disorders (PIDs) convey increased susceptibility to infections and sometimes to malignancies, particularly lymphomas. Such cancer development can be contributed by immune impairments resulting in weakened immunological surveillance against (pre)malignant cells and oncogenic viruses. Molecular defects in PID-patients are therefore being clarified, identifying new targets for innovative immunotherapy. Particularly pediatric cancers are being scrutinized, where over one-third of cancer-related deaths are accounted for by leukemia and lymphomas. Here we review how immunopathogenic mechanisms of several PIDs might associate with lymphoma development. We furthermore delineate existing immunotherapy strategies in adults for potential therapeutic application in childhood leukemia and lymphomas.
Related Concept Videos
Immunodeficiency Diseases
There are three main causes of immunodeficiency...
Tumor Immunotherapy
Increasing Function
Relative Risk
Intrinsically Disordered Proteins
Increased Body Temperature

