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Updated: Feb 13, 2026
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Fertility Preservation in Patients with Severe Ovarian Dysfunction
Published on: March 25, 2021
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[Immunosuppressive therapy and fertility preservation: Indications and methods]
C Choux1, M Cavalieri1, J Barberet2
1Service de gynécologie-obstétrique et médecine de la reproduction, hôpital François-Mitterrand, CHU de Dijon, 14, rue Paul-Gaffarel, BP 77908, 21079 Dijon cedex, France.
La Revue De Medecine Interne
|March 4, 2018
Summary
Fertility preservation is crucial for patients with immune diseases undergoing gonadotoxic treatments. Early screening and preservation methods like oocyte or sperm cryopreservation can improve future procreation chances.
Area of Science:
- Reproductive Medicine
- Immunology
- Oncology
Background:
- Immune diseases and their treatments can impair fertility in young patients.
- Fertility preservation is standard in cancer care but less so for immune conditions.
- Gonadotoxic therapies are often necessary for managing immune diseases.
Purpose of the Study:
- To review indications and methods for fertility preservation in immune disease patients.
- To highlight the impact of immune diseases and treatments on reproductive health.
- To guide clinical practice regarding fertility preservation strategies.
Main Methods:
- Literature review of fertility preservation techniques.
- Analysis of specific immunosuppressive drugs and their impact on fertility.
- Evaluation of patient-specific factors influencing preservation choices.
Main Results:
- Cyclophosphamide is the sole immunosuppressant necessitating fertility preservation in women.
- Men require fertility preservation before cyclophosphamide, methotrexate, mycophenolate mofetil, or mTOR inhibitors.
- Ovarian tissue cryopreservation (pre-puberty) and oocyte cryopreservation (post-puberty) are key for women; sperm cryopreservation for men.
Conclusions:
- Integrating infertility screening and fertility preservation is vital for immune disease patients.
- Method selection depends on age, disease activity, treatment urgency, and patient preference.
- Spermatogonia cryopreservation remains experimental for prepubertal boys.
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