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Updated: Feb 13, 2026
Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
Published on: August 15, 2025
Epileptogenic role of occult temporal encephalomeningocele: Case-control study
Sara Gasparini1, Edoardo Ferlazzo1, Giuseppe Pustorino1
1From the Department of Medical and Surgical Sciences (S.G., E.F., M.A., U.A.), "Magna Græcia" University of Catanzaro; and Regional Epilepsy Center (S.G., E.F., G.P., M.A., V.C., C.S., S.C., U.A.), Unit of Neurosurgery (M.C.), and Unit of Neuroradiology (E.A., A.G., P.V.), "Great Metropolitan Hospital," Reggio Calabria, Italy.
Objective:
The purpose of this case-control study is to evaluate the prevalence of occult temporal encephalomeningocele (OTE) in patients with temporal lobe epilepsy (TLE) of unknown etiology presenting to an epilepsy center, independently from drug sensitivity.
Methods:
We studied 95 patients with TLE (51 female, mean age 49.4 ± 17.1 years) and 151 controls (88 female, mean age 54.1 ± 21.0 years) using a 1.5T brain MRI, including balanced steady-state gradient echo sequences, targeted to the temporal lobes.
Results:
OTE was found in 5.2% of the TLE population (9.5% of drug-resistant TLE) and in none of the controls (p = 0.008). Two patients with OTE and drug-resistant TLE became seizure-free after lesionectomy (follow-up 18-24 months).
Conclusion:
OTE is not a rare finding in unselected patients with TLE of unknown origin, provided that it is carefully searched. The absence of OTE in a large group of nonepileptic controls adds evidence to its epileptogenic role.
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