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Developmental milestones at one year for the offspring of mothers with congenital hypothyroidism: a population-based

Juliane Léger1,2,3, Anne Forhan4,5, Sophie Dos Santos1

  • 1Paediatric Endocrinology Diabetology Department, Assistance Publique-Hôpitaux de Paris, Robert Debré University Hospital, Reference Center for Growth and Development Endocrine Diseases, Paris, France.

European Journal of Endocrinology
|March 4, 2018
PubMed

Insights

Children born to mothers with congenital hypothyroidism (CH) showed increased risks for poor motor coordination at one year. Uncontrolled maternal CH may impact early child development, but long-term neurodevelopmental effects require further study.

Area of Science:

  • Pediatric endocrinology
  • Neurodevelopmental pediatrics
  • Maternal-fetal medicine

Background:

  • Maternal thyroid dysfunction during pregnancy is linked to offspring neurodevelopmental issues.
  • Limited data exist on developmental outcomes for children born to mothers treated for congenital hypothyroidism (CH).

Purpose of the Study:

  • To investigate motor and language milestones at one year of age in children born to mothers with CH.
  • To assess the impact of maternal CH on early childhood development.

Main Methods:

  • A population-based registry of children born to mothers with CH was compared with the EDEN French birth cohort.
  • 110 children of mothers with CH and 1367 controls were assessed at one year using identical developmental milestone questionnaires.
  • Outcomes included mobility, motor coordination, communication, motricity, and language skills.

Main Results:

  • Children born to mothers with CH had a significantly higher risk of poor motor coordination (OR: 4.18).
  • No differences were observed in other developmental domains.
  • Maternal gestational diabetes also increased the risk of low motor coordination (OR: 2.10).
  • Maternal TSH ≥ 10 IU/L in early pregnancy was associated with lower motricity and communication scores.

Conclusions:

  • Maternal CH may have minor adverse effects on specific developmental milestones in one-year-old children.
  • Children born to mothers with uncontrolled hypothyroidism appear more affected.
  • The long-term impact of these early effects on subsequent neurodevelopment remains uncertain.
Abstract

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