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[Development and treatment of localized/systemic BCGitis : Retrospective studies in direct comparison to mitomycin C]
W-D U Böhm1, R Koch2, S Wenzel3
1Akademische Lehrpraxis für Urologie, Ärztehaus am Krankenhaus St. Joseph-Stift Dresden, Dresden, Deutschland. dr.wolf-diether.boehm@gmx.de.
Abstract:
Adjuvant therapy with different bacillus Calmette-Guérin (BCG) preparations is a well-established guideline-endorsed treatment for nonmuscle invasive bladder cancer (NMIBC). Our observational study demonstrates equality between BCG and mitomycin C (MMC) treatment based on the oncological outcome. However, there were significant toxicity differences with higher rates in the BCG treatment group. The potential adverse effects of BCG in terms of a BCGitis are controversially discussed regarding their occurrence. As such, we sought to retrospectively evaluate the incidence in 106 consecutive patients. The BCG group demonstrated minor adverse effects in 78.4% and major adverse effects in 43.3%-partially coincident. Moreover, the parallel MMC group showed in 34.7% respectively 1.4% adverse events-as expected distinctly lower. In the context of this clinical discussion, we refer to alternative treatment concepts. Our data show a high clinical relevance of the patient's primary comorbidity.
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