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Vitamin K2 in multiple sclerosis patients.

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Multiple sclerosis (MS) patients have significantly lower vitamin K2 (VK2) levels than healthy individuals. Lower VK2 may be linked to disease progression, suggesting a need for further research into VK2

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Area of Science:

  • Biochemistry
  • Neurology
  • Immunology

Background:

  • Vitamin K2 (VK2) is crucial for physiological functions, including mitochondrial protection.
  • VK2's role in preventing mitochondrial damage suggests potential relevance in managing multiple sclerosis (MS) progression.

Purpose of the Study:

  • To investigate serum vitamin K2 (VK2) levels in multiple sclerosis (MS) patients compared to healthy controls.
  • To explore the relationship between VK2 levels and MS disease characteristics.

Main Methods:

  • Serum VK2 levels were measured using Enzyme-linked Immunosorbent Assay (ELISA).
  • The study included 45 MS patients and 29 healthy controls, all receiving vitamin D supplementation.
  • VK2 levels were correlated with disease characteristics such as attacks per year and optic nerve lesions.

Main Results:

  • MS patients exhibited substantially lower VK2 blood levels (235 ± 100 ng/ml) compared to controls (812 ± 154 ng/ml).
  • Female MS patients had significantly lower VK2 levels than males.
  • VK2 levels decreased with age and were associated with increased disease activity (attacks per year) and optic nerve lesions.

Conclusions:

  • Substantially lower VK2 levels in MS patients may result from depletion, reduced gut production, or impaired absorption.
  • The potential role of vitamin K2 in the development and progression of multiple sclerosis warrants further investigation.