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Stability of dobutamine in continuous ambulatory delivery devices

F Al Madfai1, B Valah1, S T R Zaidi1

  • 1Division of Pharmacy, School of Medicine, University of Tasmania, Hobart, TAS, Australia.

Journal of Clinical Pharmacy and Therapeutics
|March 4, 2018
PubMed

Insights

Dobutamine is chemically stable in continuous ambulatory delivery devices (CADDs) for at least 168 hours at 4°C, plus additional time at higher temperatures. This stability supports weekly CADD supplies for home infusions in heart failure patients.

Area of Science:

  • Pharmacology
  • Pharmaceutical Science
  • Clinical Pharmacy

Background:

  • Continuous dobutamine infusion is vital for end-stage heart failure management.
  • Home infusion via CADDs improves patient care and reduces hospitalization.
  • The stability of dobutamine in CADDs was previously unknown.

Purpose of the Study:

  • To investigate the physicochemical stability of dobutamine in CADDs.
  • To assess dobutamine stability at various temperatures and time points.
  • To inform home infusion protocols for heart failure patients.

Main Methods:

  • Prepared CADDs with dobutamine in 0.9% sodium chloride or 5% glucose.
  • Stored CADDs at 4°C, 35°C, and 25°C for specified durations.
  • Analyzed dobutamine concentration, pH, color, and particle content using HPLC.

Main Results:

  • No changes in particle formation, color, or pH were observed.
  • Dobutamine demonstrated chemical stability for at least 168 hours at 4°C.
  • Stability was maintained for an additional 12 hours at 35°C and 12 hours at 25°C.

Conclusions:

  • Dobutamine is chemically stable in CADDs under the tested conditions.
  • Findings support weekly dispensing of dobutamine CADDs for home use.
  • This can reduce CADD exchanges and lower infection risk in heart failure patients.
Abstract

Keywords:
chromatographycontinuous infusion devicedobutaminestability

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