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The association between depression and coronary artery calcification: A meta-analysis of observational studies

Song Lin1, Huaqi Zhang1, Aiguo Ma1

  • 1The College of Public Health, Qingdao University, 38 Dengzhou Road, Qingdao, Shandong 266021, China.

Journal of Affective Disorders
|March 4, 2018
PubMed

Insights

Diagnosed depression is linked to a higher likelihood of coronary artery calcification (CAC). This meta-analysis suggests screening for CAC in depressed patients to assess cardiovascular disease risk.

Area of Science:

  • Cardiology
  • Psychiatry
  • Epidemiology

Background:

  • Cardiovascular diseases and depression represent a significant global health burden.
  • The relationship between depression and coronary artery calcification (CAC) is not well-established.
  • A quantitative meta-analysis on this association was lacking.

Purpose of the Study:

  • To evaluate the association between depression and coronary artery calcification (CAC).
  • To provide a quantitative synthesis of existing observational studies.

Main Methods:

  • A systematic literature search was conducted across major databases (PubMed, Web of Science, Embase, etc.) up to April 2017.
  • Included 15 observational studies with 32,884 participants.
  • Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a random effects model, including subgroup analyses.

Main Results:

  • A significant positive association was found between diagnosed depression and CAC (OR = 1.15; 95% CI: 1.04-1.28).
  • No significant association was observed between depressive symptoms and CAC (OR = 1.02; 95% CI: 0.97-1.07).
  • Subgroup analysis of cohort studies showed an enhanced positive association for diagnosed depression and CAC (OR = 2.20; 95% CI: 1.33-3.64).

Conclusions:

  • Diagnosed depression is associated with increased odds of coronary artery calcification (CAC).
  • Systematic screening for CAC may benefit clinically depressed individuals.
  • Identifying high-risk patients can aid in preventing future cardiovascular diseases.
Abstract

Keywords:
Cardiovascular diseasesCoronary artery calcificationDepressionMeta-analysis

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