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Psychiatric symptoms delay the diagnosis of anti-LGI1 encephalitis

Yoonhyuk Jang1, Soon-Tae Lee1, Jung-Ah Lim2

  • 1Department of Neurology, Seoul National University Hospital, Seoul, South Korea; Program in Neuroscience, Neuroscience Research Institute of SNUMRC, College of Medicine, Seoul National University, Seoul, South Korea.

Journal of Neuroimmunology
|March 5, 2018
PubMed

The aim of this study was to analyze the detailed characteristics of the psychiatric symptoms in patients with anti-LGI1 encephalitis. Of 16 patients, ten showed psychiatric symptoms as the initial manifestations. All 10 patients experienced mood-related symptoms. The time to immune therapy was longer in those with initial psychiatric symptoms compared to those without them. Initial manifestation of psychiatric symptoms in patients with anti-LGI1 encephalitis may be a poor prognostic factor, at least in the short term, in that it misleads both the patients and the clinicians to neglect the typically accompanied symptoms of the disease such as faciobrachial dystonic seizure, delaying the timing of immune therapy.

Keywords:
Anti-LGI1 encephalitisDementiaEpilepsy-related psychosisPrognostic factorPsychiatric symptomSenile depression

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