Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Kinases and Phosphatases02:54

Protein Kinases and Phosphatases

15.2K
Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
15.2K
Protein Kinases and Phosphatases02:54

Protein Kinases and Phosphatases

4.5K
4.5K
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

9.7K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
9.7K
Regulated Protein Degradation02:58

Regulated Protein Degradation

8.9K
It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
8.9K
Positive Regulator Molecules01:45

Positive Regulator Molecules

136.5K
To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
136.5K
Receptor Tyrosine Kinases01:26

Receptor Tyrosine Kinases

19.0K
Receptor tyrosine kinases or RTKs are membrane-bound receptors that phosphorylate specific tyrosine on protein substrates. RTKs regulate cellular growth, differentiation, survival, and migration. They contain an extracellular ligand binding domain, a transmembrane domain, and a cytosolic tail with intrinsic kinase activity. Several extracellular signaling molecules activate RTKs in one or more ways and relay the signal downstream. Ligands such as platelet-derived growth factor (PDGF) or...
19.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Placental and cord blood DNA methylation in preterm birth: exploring the epigenetic role of maternal dietary protein.

NPJ science of food·2025
Same author

Placental and Cord Blood DNA Methylation Changes Associated With Gestational Diabetes Mellitus in a Marginalized Population: The Untold Role of Saturated Fats.

Molecular nutrition & food research·2025
Same author

Exploring the composition of placental microbiome and its potential origin in preterm birth.

Frontiers in cellular and infection microbiology·2025
Same author

Single-Nucleus RNA Sequencing Reveals Loss of Distal Convoluted Tubule 1 Renal Tubules in HIV Viral Protein R Transgenic Mice.

The American journal of pathology·2024
Same author

Design of a targeted blood transcriptional panel for monitoring immunological changes accompanying pregnancy.

Frontiers in immunology·2024
Same author

Unveiling the dynamics of the breast milk microbiome: impact of lactation stage and gestational age.

Journal of translational medicine·2023

Related Experiment Video

Updated: Feb 13, 2026

Noninvasive Intratracheal Intubation to Study the Pathology and Physiology of Mouse Lung
05:15

Noninvasive Intratracheal Intubation to Study the Pathology and Physiology of Mouse Lung

Published on: November 8, 2013

25.7K

GR-regulating Serine/Threonine Kinases: New Physiologic and Pathologic Implications.

Tomoshige Kino1

  • 1Department of Human Genetics, Division of Translational Medicine, Sidra Medical and Research Center, Doha 26999, Qatar.

Trends in Endocrinology and Metabolism: TEM
|March 5, 2018
PubMed
Summary

Glucocorticoid hormones, regulated by the hypothalamic-pituitary-adrenal axis, impact human functions. This review explores how glucocorticoid receptor (GR) phosphorylation by kinases modulates these crucial hormonal actions.

Keywords:
N-terminal domainglucose metabolismleukemiasubcellular shuttlingtranscriptional cofactorstranscriptional regulation

More Related Videos

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
12:26

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

Published on: May 3, 2018

19.4K
A Simple Method to Identify Kinases That Regulate Embryonic Stem Cell Pluripotency by High-throughput Inhibitor Screening
07:18

A Simple Method to Identify Kinases That Regulate Embryonic Stem Cell Pluripotency by High-throughput Inhibitor Screening

Published on: May 12, 2017

6.8K

Related Experiment Videos

Last Updated: Feb 13, 2026

Noninvasive Intratracheal Intubation to Study the Pathology and Physiology of Mouse Lung
05:15

Noninvasive Intratracheal Intubation to Study the Pathology and Physiology of Mouse Lung

Published on: November 8, 2013

25.7K
Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
12:26

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

Published on: May 3, 2018

19.4K
A Simple Method to Identify Kinases That Regulate Embryonic Stem Cell Pluripotency by High-throughput Inhibitor Screening
07:18

A Simple Method to Identify Kinases That Regulate Embryonic Stem Cell Pluripotency by High-throughput Inhibitor Screening

Published on: May 12, 2017

6.8K

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Cell Signaling

Background:

  • Glucocorticoid hormones are key regulators of homeostasis and stress response.
  • The glucocorticoid receptor (GR) mediates these effects as a ligand-dependent transcription factor.
  • Local biological pathways frequently target the GR signaling pathway for regulation.

Purpose of the Study:

  • To review recent advancements in understanding GR phosphorylation.
  • To discuss the physiological and pathophysiological relevance of GR phosphorylation.
  • To highlight the role of serine/threonine kinases in GR regulation.

Main Methods:

  • Literature review of recent research on GR phosphorylation.
  • Analysis of studies investigating kinase interactions with GR.
  • Synthesis of data on the functional consequences of GR phosphorylation.

Main Results:

  • Phosphorylation by serine/threonine kinases is a primary mechanism for regulating GR activity.
  • Specific phosphorylation sites on GR influence its transcriptional activity and cellular localization.
  • Dysregulated GR phosphorylation is implicated in various pathophysiological conditions.

Conclusions:

  • GR phosphorylation is a critical regulatory node in glucocorticoid signaling.
  • Understanding GR phosphorylation offers insights into treating diseases involving the hypothalamic-pituitary-adrenal axis.
  • Further research into kinase-specific regulation of GR is warranted.