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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
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Interstitial lung abnormalities are associated with increased mortality in smokers
Nils Hoyer1, Mathilde M W Wille2, Laura H Thomsen3
1Department of Respiratory Medicine, Herlev and Gentofte Hospital, Copenhagen, Denmark.
Respiratory Medicine
|March 5, 2018
Summary
Smokers with interstitial lung abnormalities (ILAs) face higher mortality risks. These findings, identified on CT scans, are linked to lung cancer and other malignancies, underscoring the importance of ILAs in risk assessment.
Area of Science:
- Pulmonology
- Radiology
- Oncology
Background:
- Interstitial lung abnormalities (ILAs) are increasingly detected incidentally on CT scans.
- Smokers are a key demographic for lung cancer screening, often exhibiting various lung pathologies.
Purpose of the Study:
- To determine if smokers with incidental ILAs have increased long-term mortality.
- To identify the causes of death associated with ILAs in this cohort.
Main Methods:
- Qualitative assessment of CT scans from 1990 participants in the Danish Lung Cancer Screening Trial.
- Inclusion criteria: current/former smokers, >20 pack-years, age 50-70.
- Follow-up for up to 12 years.
Main Results:
- ILAs were found in 16.7% of participants.
- ILAs significantly increased all-cause mortality (HR: 2.0) and mortality in lung cancer-free individuals (HR: 1.6).
- ILAs were associated with increased risk of death from lung cancer (HR: 3.2) and non-pulmonary malignancies (HR: 2.1).
Conclusions:
- Interstitial lung abnormalities are prevalent in smokers undergoing lung cancer screening.
- ILAs are associated with increased mortality, irrespective of their specific type (fibrotic or non-fibrotic).
- The elevated mortality risk is partly attributed to associations with lung cancer and other malignancies.
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