Patient-Reported Outcome Measures in Carotid Artery Revascularization: Systematic Review and Psychometric Analysis

Area of Science:

• Medical research
• Health outcomes research
• Clinical trial methodology

Background:

• Patient-reported outcome measures (PROMs) assess disease impact on quality of life (QoL).
• Carotid artery stenosis (CAS) revascularization outcomes require patient-centered evaluation.

Purpose of the Study:

• Identify and assess PROMs for CAS patients undergoing revascularization.
• Evaluate psychometric properties and suitability for clinical and research use.

Main Methods:

• Systematic review of 8 electronic databases.
• Searched for development/validation of PROMs in CAS revascularization.
• Assessed study quality using COnsensus-based Standards for the selection of health Measurement INstruments and Oxford criteria.

Main Results:

• Six PROMs identified across 5 studies (SF-36, EQ-5D, HADS, DHI, QoL-CAS, disease-specific PROM).
• Psychometric properties were variable; most assessed only one criterion.
• No studies reported construct validity or test-retest reliability; overall psychometric evaluation was poor.

Conclusions:

• Significant lack of validated PROMs for CAS patients undergoing revascularization.
• Development of a new, validated PROM is warranted for this population.
• New PROMs can supplement clinical outcomes and inform treatment decisions.