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Updated: Feb 13, 2026
08:50
Predictive Immune Modeling of Solid Tumors
Published on: February 25, 2020
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Long non-coding RNA CRNDE as a potential prognostic biomarker in solid tumors: A meta-analysis
Chaojie Liang1, Bing Zhang2, Hua Ge1
1Department of General Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
Summary
High expression of colorectal neoplasia differentially expressed (CRNDE) long non-coding RNA is linked to advanced cancer stages and poor survival. CRNDE shows potential as a prognostic biomarker in human cancers.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Long non-coding RNA colorectal neoplasia differentially expressed (CRNDE) is upregulated in various cancers.
- Previous studies on CRNDE's role in cancer were limited by small sample sizes.
- The precise role of CRNDE in cancer progression and prognosis requires further investigation.
Purpose of the Study:
- To conduct a comprehensive meta-analysis assessing the association between CRNDE expression and cancer.
- To evaluate CRNDE's correlation with clinicopathological characteristics and patient prognosis.
- To determine if CRNDE can serve as a reliable prognostic biomarker in human cancers.
Main Methods:
- Systematic literature search across major databases (PubMed, Medline, Cochrane Library, Web of Science, EMBASE, Ovid, CNKI, WanFang).
- Inclusion of 13 studies involving 1570 cancer patients.
- Statistical analysis using pooled odds ratios (ORs) and hazard ratios (HRs) with 95% confidence intervals (CI) to assess CRNDE's impact.
Main Results:
- High CRNDE expression correlated with lymph node metastasis (OR = 3.50) and advanced TNM stage (OR = 0.26).
- No significant association was found between CRNDE expression and gender, tumor size, or differentiation.
- Elevated CRNDE expression was linked to poorer overall survival (OS) (HR = 2.06) and identified as an independent predictor of OS (HR = 1.62).
Conclusions:
- High CRNDE expression is associated with advanced clinicopathological features in cancer.
- CRNDE demonstrates potential as a prognostic biomarker for human cancers.
- Further high-quality studies with larger sample sizes are recommended to validate these findings.
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