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Related Concept Videos

Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

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Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
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Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

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Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
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Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

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Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
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Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

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Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
2
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

2
Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
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Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

3
Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
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Related Experiment Video

Updated: Feb 13, 2026

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
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Responsive triggering systems for delivery in chronic wound healing.

Mangesh Morey1, Abhay Pandit1

  • 1CÚRAM, Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland.

Advanced Drug Delivery Reviews
|March 5, 2018
PubMed
Summary
This summary is machine-generated.

Advanced drug delivery systems are needed for chronic diseases like cancer and diabetes. This review explores stimuli-responsive systems for better wound healing, focusing on overcoming current limitations.

Keywords:
Drug deliveryOn-demand deliveryResponsive polymersStimuli responsive

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Non-communicable diseases (NCDs) like cancer, cardiovascular disease, diabetes, and neuropathy are chronic and challenging to treat.
  • Traditional drug delivery methods lack site-specificity, controlled release, and adequate dosing for chronic wound management.
  • Existing responsive delivery systems offer potential but require further development for complex wound conditions.

Purpose of the Study:

  • To critically assess recent advancements in stimuli-responsive drug delivery systems for chronic wounds.
  • To highlight the limitations of current responsive delivery technologies.
  • To provide perspectives on overcoming challenges in developing next-generation delivery systems.

Main Methods:

  • Literature review of recent developments in stimuli-responsive delivery systems.
  • Analysis of multifactorial approaches including spatiotemporal release, multimodal systems, and dual/multi-stimuli responsiveness.
  • Evaluation of systems loaded with single or multiple bioactive components.

Main Results:

  • Responsive delivery systems offer potential for improved site-specificity and controlled release.
  • Multifactorial and multi-stimuli responsive systems show promise for complex wound management.
  • Current technologies face limitations in achieving the necessary spatiotemporal control and feasibility for clinical application.

Conclusions:

  • Next-generation stimuli-responsive delivery systems are crucial for effectively treating chronic wounds.
  • Overcoming limitations in current technologies is essential for developing feasible and advanced wound care solutions.
  • Further research into fabricating sophisticated, responsive systems is required.