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Lumican as a multivalent effector in wound healing.

Konstantina Karamanou1, Gwenn Perrot2, Francois-Xavier Maquart3

  • 1Université de Reims Champagne-Ardenne, Laboratoire de Biochimie Médicale et Biologie Moléculaire, Reims, France; Biochemistry, Biochemical Analysis & Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, Patras, Greece; CNRS UMR 7369, Matrice Extracellulaire et Dynamique Cellulaire, Reims, France.

Advanced Drug Delivery Reviews
|March 5, 2018
PubMed
Summary

Lumican, a key protein in extracellular matrices, significantly promotes normal wound repair. This review highlights its crucial role in skin and corneal healing, offering new therapeutic avenues for impaired healing processes.

Keywords:
CorneaHypertrophic scarsKeratinocytesKeratocytesLumicanSkinWound healing

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Area of Science:

  • Biochemistry
  • Cell Biology
  • Regenerative Medicine

Background:

  • Wound healing is a complex physiological process for tissue repair, often studied in skin and cornea.
  • Lumican, a small leucine-rich proteoglycan, is vital in extracellular matrices of tissues like the cornea, cartilage, and skin.
  • Lumican regulates collagen fibrillogenesis, keratinocyte phenotypes, and corneal transparency, and is involved in inflammatory cell extravasation and angiogenesis.

Purpose of the Study:

  • To review the critical role of lumican in wound healing processes.
  • To discuss potential drug delivery methods for targeting lumican in wound repair.
  • To emphasize lumican's mechanisms of action in corneal and skin wound healing.

Main Methods:

  • Literature review of in vitro and in vivo studies on lumican's role in wound healing.
  • Analysis of lumican's expression patterns and functional significance in different tissue types.
  • Examination of regulatory pathways involving lumican in tissue repair.

Main Results:

  • Lumican is uniquely expressed by epithelia during wound healing and is essential for normal repair.
  • Studies demonstrate lumican's involvement in regulating key aspects of stromal wound healing, including inflammation and angiogenesis.
  • Lumican's function in corneal transparency and skin healing is elucidated through various experimental models.

Conclusions:

  • Lumican plays a fundamental role in promoting effective wound healing across multiple tissues.
  • Understanding lumican's mechanisms opens therapeutic strategies for conditions with impaired wound healing.
  • Targeted delivery of lumican presents a promising approach for enhancing tissue regeneration.