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Related Experiment Video

Updated: Feb 13, 2026

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
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Maximizing Sentinel Lymph Node Detection: Aortic Sentinel Lymph Node Detection in Endometrial Cancer.

Mikel Gorostidi1, Cecilia Villalain2, Ruben Ruiz1

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Journal of Minimally Invasive Gynecology
|March 5, 2018
PubMed
Summary

Dual indocyanine green (ICG) injection improves sentinel lymph node (SLN) detection in endometrial cancer (EC) by mapping both pelvic and para-aortic regions. This comprehensive approach maximizes identification of potentially affected areas without increasing morbidity.

Keywords:
Endometrial cancerIndocyanin greenSentinel lymph node

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Area of Science:

  • Gynecologic Oncology
  • Surgical Innovation
  • Cancer Staging

Background:

  • Sentinel lymph node (SLN) biopsy is crucial for accurate staging of endometrial cancer (EC).
  • Traditional methods may miss metastases in non-pelvic lymph nodes.
  • Indocyanine green (ICG) has emerged as a valuable tool for SLN detection.

Observation:

  • A dual injection technique using ICG, combining cervical and fundal administration, was employed for SLN detection in EC.
  • This method aimed to enhance visualization of both pelvic and para-aortic lymph node basins.
  • The procedure involved a step-by-step demonstration of the surgical technique.

Findings:

  • Dual ICG injection facilitated comprehensive mapping of SLNs, including those in the para-aortic region, which are often overlooked.
  • The final histology confirmed micrometastasis in both aortic and pelvic lymph nodes, upgrading the EC stage.
  • While operative time may increase, the dual injection technique did not add to patient morbidity.

Implications:

  • Dual ICG injection offers a more complete SLN mapping strategy for EC, potentially improving staging accuracy.
  • This technique maximizes the identification of all potentially affected lymphatic areas.
  • Further research is warranted to fully elucidate the clinical significance and benefits of this dual injection approach in EC management.