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Binary polyhydroxyalkanoate systems for soft tissue engineering.

Barbara Lukasiewicz1, Pooja Basnett1, Rinat Nigmatullin2

  • 1Applied Biotechnology Research Group, Department of Life Sciences, Faculty of Science and Technology, University of Westminster, London W1W 6UW, UK.

Acta Biomaterialia
|March 5, 2018
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Summary

Researchers developed a novel plasticizer from a related polymer to improve the flexibility of poly(3-hydroxybutyrate) (P(3HB)). This advancement creates more pliable biomaterials for tissue engineering applications, enhancing cell compatibility.

Keywords:
Oligomeric plasticiserPolyhydroxyalkanoatesSoft tissue engineeringmcl-PHAsscl-PHAs

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Poly(3-hydroxybutyrate) (P(3HB)) is a natural, biodegradable polyester with potential biomedical uses.
  • Its inherent brittleness limits applications in tissue engineering.
  • Plasticizers are used to improve polymer flexibility but raise concerns regarding toxicity and migration in biomedical contexts.

Purpose of the Study:

  • To overcome the brittleness of P(3HB) by developing a safe and effective plasticizer.
  • To enhance the mechanical properties and expand the biomedical applications of P(3HB).
  • To create more pliable biomaterials for soft tissue engineering.

Main Methods:

  • Synthesized a medium-chain-length polyhydroxyalkanoate (mcl-PHA) copolymer using waste frying oil.
  • Derived an oligomeric plasticizer from the mcl-PHA via acid hydrolysis.
  • Blended the oligomeric mcl-PHA with P(3HB) and characterized thermal and mechanical properties.
  • Assessed in vitro biocompatibility using C2C12 myoblast cells.

Main Results:

  • Addition of oligomeric mcl-PHA significantly increased the flexibility and reduced the crystallinity of P(3HB).
  • Materials with over 10 wt% oligomeric mcl-PHA showed a dominant amorphous phase.
  • The modified P(3HB) blends exhibited excellent C2C12 cell viability and proliferation.
  • The plasticized P(3HB) demonstrated improved ductility and mechanical properties.

Conclusions:

  • Oligomeric mcl-PHA effectively plasticizes P(3HB), creating softer and more flexible PHA-based materials.
  • This approach yields biocompatible, pliable biomaterials suitable for soft tissue engineering.
  • The use of waste frying oil as a carbon source offers a sustainable route to PHA production.