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New flavonoids from Portulaca oleracea L. and their activities
Xu Yang1, Wenjie Zhang1, Xixiang Ying1
1School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, PR China.
Fitoterapia
|March 5, 2018
Summary
Three new compounds and three known compounds were isolated from Portulaca oleracea. Oleracone C, D, and E showed significant antioxidant and anticholinesterase activities, indicating potential therapeutic applications.
Area of Science:
- Phytochemistry
- Natural Products Chemistry
- Pharmacology
Background:
- Portulaca oleracea L. (purslane) is a widely distributed plant with a history of traditional medicinal use.
- Investigating the chemical constituents of P. oleracea can lead to the discovery of novel bioactive compounds.
Purpose of the Study:
- To isolate and characterize new and known compounds from Portulaca oleracea.
- To evaluate the antioxidant and anticholinesterase activities of the isolated compounds.
Main Methods:
- Isolation of compounds using chromatographic techniques.
- Structure elucidation through comprehensive spectroscopic methods including 1D/2D NMR, HR-ESI-TOF-MS, and CD spectrometry.
- In vitro assays for DPPH radical scavenging and anticholinesterase activity.
Main Results:
- Six compounds were isolated: three new (oleracone C, D, E, and cycloflavan 3) and three known flavanone and chalcone derivatives.
- Oleracone C, D, and E exhibited DPPH radical scavenging activity with IC50 values ranging from 11.73 to 23.27 μM.
- These compounds also demonstrated anticholinesterase activity with IC50 values between 59.55 and 78.85 μM.
Conclusions:
- The study successfully identified novel compounds from Portulaca oleracea.
- Oleracone C, D, and E possess significant antioxidant and anticholinesterase properties, suggesting their potential as therapeutic agents.
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