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Economic burden of cirrhosis in Catalonia: a population-based analysis
Mireia Miquel1,2, Montserrat Clèries3, Mercedes Vergara1,2
1Hepatology Unit, Digestive Disease Department, Parc Tauli Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí I3PT, Universitat Autònoma de Barcelona, Sabadell, Spain.
Insights
Cirrhosis patients incur significant healthcare costs, with hospitalizations being the largest expense. Understanding resource use is crucial for managing this chronic disease effectively.
Area of Science:
- Hepatology
- Public Health
- Health Economics
Background:
- Cirrhosis is a severe chronic liver disease associated with high morbidity and mortality rates.
- Limited research exists on the healthcare resource utilization patterns of patients with cirrhosis.
Purpose of the Study:
- To determine the point prevalence of cirrhosis in Catalonia, Spain, as of December 31, 2012.
- To analyze healthcare resource use and expenditures in a general population of cirrhosis patients in 2013.
- To stratify analysis by disease compensation status and comorbidity burden.
Main Methods:
- Population-based study utilizing International Classification of Diseases, ninth revision (ICD-9) data for cirrhosis diagnosis.
- Inclusion of all adult patients diagnosed with cirrhosis in Catalonia, Spain, on December 31, 2012.
- Evaluation of healthcare resource use and expenditures throughout 2013, considering decompensation status prior to or during 2012.
Main Results:
- Identified 34,740 cirrhosis patients, a point prevalence of 460 per 100,000 inhabitants.
- Total healthcare expenditures for cirrhosis patients in 2013 reached €142.1 million, 1.8% of Catalonia's healthcare budget.
- Hospitalizations constituted 35.1% of total expenditures; key predictors of high expenditure included comorbidity burden and prior hospitalizations.
Conclusions:
- Cirrhosis represents a substantial burden on healthcare resources, particularly concerning hospitalization costs.
- Comorbidity, HIV infection, and prior healthcare utilization are significant drivers of expenditure in cirrhosis patients.
Background:
Cirrhosis is a chronic disease with high morbidity and mortality. Few studies have evaluated healthcare resource use in patients with cirrhosis.
Objective:
We aimed to describe the point prevalence of cirrhosis on 31 December 2012 and the population-level distribution of healthcare resource use and expenditures in a non-selected population of patients with cirrhosis, stratified by whether their disease was compensated or decompensated, and by comorbidity burden.
Methods:
This population study included all known patients aged >18 years with cirrhosis (according to International Classification of Diseases, ninth revision) in Catalonia, Spain, on 31 December 2012. We evaluated healthcare resource use and expenditure during 2013, taking into account the presence of decompensation before or during 2012.
Results:
We documented 34 740 patients diagnosed with cirrhosis (58.7% men; mean age 61.8±14 years), yielding a point prevalence of 460 per 100 000 inhabitants on 31 December 2012. Annual mortality was 9.1%. During 2013, healthcare expenditures on patients with cirrhosis totalled €142.1 million (€4234 per patient), representing 1.8% of the total 2013 healthcare budget of Catalonia. Hospitalisation costs accounted for 35.1% of the total expenditure and outpatient care accounted for 22.4%. MultivariateMultivariate logistic regression identified morbidity burden, HIV infection, hospitalisation and emergency room visits during 2012 as independent predictors of expenditure above the 85th centile (area under the receiver operating curve, 0.88 (95% CI 0.883 to 0.893, P<0.001)).
Conclusions:
Cirrhosis accounts for a high proportion of healthcare resource usage and expenditures; hospitalisation accounted for the highest expenditures.
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