Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

768
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
768
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

688
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
688
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

485
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
485
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

416
Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
416
Kidney Structure01:45

Kidney Structure

75.5K
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
75.5K
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

210
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
210

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>Clostridioides difficile</i> osteomyelitis presenting as a Brodie's abscess of the tibia.

BMJ case reports·2026
Same author

Chronic hyponatraemia with a reset osmostat: when abnormal is normal.

Pediatric nephrology (Berlin, Germany)·2026
Same author

Essential but elusive: the availability of suitable salt treatments for tubulopathies.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same author

Anti-HMGCR Myopathy During NSTEMI Evaluation: The Statin Paradox and Troponin Trap.

JACC. Case reports·2026
Same author

Renal Fanconi syndrome and vitamin D deficiency: chicken or egg?

Pediatric nephrology (Berlin, Germany)·2026
Same author

BPI26-029: Analysis of Racial Demographic Reporting in Clinical Studies Supporting the NCCN Esophageal & Esophagogastric Junction Cancer Guidelines.

Journal of the National Comprehensive Cancer Network : JNCCN·2026
Same journal

Characterizing children with chronic kidney disease and severe proteinuria in the United States: a retrospective analysis using electronic health records.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

New therapeutic hope for rare podocytopathies.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

Expression of PD-1 on T cells and its predictive value for steroid resistance in children with idiopathic nephrotic syndrome.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

Real-world experience of using vitamin E for symptomatic management of muscle cramps in children living with chronic kidney disease.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

Feasibility and comparability in pediatric donation after circulatory death kidney transplantation.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

APOM-S1P axis as a therapeutic target in steroid sensitive nephrotic syndrome.

Pediatric nephrology (Berlin, Germany)·2026
See all related articles

Related Experiment Video

Updated: Feb 13, 2026

A Possible Zebrafish Model of Polycystic Kidney Disease: Knockdown of wnt5a Causes Cysts in Zebrafish Kidneys
10:51

A Possible Zebrafish Model of Polycystic Kidney Disease: Knockdown of wnt5a Causes Cysts in Zebrafish Kidneys

Published on: December 2, 2014

11.5K

Zebrafish as a model for kidney function and disease.

Priya Outtandy1,2, Claire Russell2, Robert Kleta3

  • 1Centre for Nephrology, Royal Free Hospital/Medical School, University College London, 1. Floor, Room 1.7007, Rowland Hill Street, London, NW3 2PF, UK.

Pediatric Nephrology (Berlin, Germany)
|March 5, 2018
PubMed
Summary
This summary is machine-generated.

Zebrafish offer a valuable model for studying kidney diseases, advancing nephrology research. Their use helps understand disease mechanisms and screen treatments while minimizing mammalian animal use.

Keywords:
Acute kidney injuryAnimal modelChronic kidney diseaseKidneyPolycystic kidney diseaseRenal diseasesZebrafish

More Related Videos

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury
07:58

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury

Published on: July 17, 2016

9.3K
Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

18.7K

Related Experiment Videos

Last Updated: Feb 13, 2026

A Possible Zebrafish Model of Polycystic Kidney Disease: Knockdown of wnt5a Causes Cysts in Zebrafish Kidneys
10:51

A Possible Zebrafish Model of Polycystic Kidney Disease: Knockdown of wnt5a Causes Cysts in Zebrafish Kidneys

Published on: December 2, 2014

11.5K
Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury
07:58

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury

Published on: July 17, 2016

9.3K
Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

18.7K

Area of Science:

  • Nephrology
  • Comparative Anatomy
  • Translational Medicine

Background:

  • Kidney disease is a growing global health concern with rising incidence.
  • Effective treatments require a deeper understanding of kidney disease pathophysiology.
  • Minimizing mammalian animal use in research is crucial for animal welfare.

Purpose of the Study:

  • To discuss the utility of zebrafish as a model organism in nephrology.
  • To highlight how zebrafish advance the study of kidney disease mechanisms.
  • To explore zebrafish in screening therapeutic compounds for kidney disorders.

Main Methods:

  • Utilizing zebrafish for genetic tractability studies.
  • Comparing zebrafish renal anatomy to mammalian kidneys.
  • Investigating glomerular and tubular filtration processes in zebrafish.

Main Results:

  • Zebrafish possess a renal anatomy comparable to mammals.
  • Zebrafish exhibit glomerular and tubular filtration functions.
  • Zebrafish models facilitate the study of kidney disease mechanisms.

Conclusions:

  • Zebrafish are a powerful and ethically sound model for nephrology research.
  • Zebrafish facilitate advancements in understanding and treating kidney diseases.
  • The use of zebrafish aids in the development of novel therapeutic strategies.