Design, Synthesis, and Evaluation of New Sulfone Derivatives Containing a 1,3,4-Oxadiazole Moiety as Active
Pei Li1,2, Deyu Hu1, Dandan Xie1
1State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering; Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education; Research and Development Center for Fine Chemicals , Guizhou University , Guiyang 550025 , P. R. China.
Abstract:
This study aimed to synthesize some new sulfone derivatives containing a 1,3,4-oxadiazole moiety and investigate their in vitro antibacterial activities against Xanthomonas oryzae pv. oryzae ( Xoo) and Xanthomonas axonopodis pv. citri ( Xac), the pathogens of rice bacterial leaf blight and citrus canker, respectively, by performing turbidimeter tests. Antibacterial bioassay results showed that compound 6d revealed excellent bioactivities against Xoo and Xac, with the 50% effective concentration (EC50) values of 0.17 and 1.98 μg/mL, respectively, compared with thiodiazole copper (121.82 and 77.04 μg/mL, respectively) and bismerthiazol (92.61 and 58.21 μg/mL, respectively). Meanwhile, greenhouse-condition trials indicated that, compared with thiodiazole copper and bismerthiazol, compound 6d more effectively reduced rice bacterial leaf blight.
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