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Published on: September 30, 2021
Diverse effects of interleukin-22 on pancreatic diseases
Xiuyun Xuan1, Zhiqiang Tian2, Mengjie Zhang3
1Department of Pathophysiology, Third Military Medical University, Chongqing, 400038, China; Department of Microbiology and Immunology, Shanxi Medical University, Taiyuan, 030200, China.
Abstract:
Interleukin-22 (IL-22) is involved in the development of lymphocytes and serves as a rapid and early source of the effector cytokines that are released in response to pathogen-induced changes in the microenvironment. Recent research has implicated IL-22 as a potential contributing factor to the spectrum of inflammation-related pancreatic diseases, particularly pancreatitis, fibrosis, carcinoma and diabetes. In this review, we summarize the current knowledge on the roles of IL-22 in the various pancreatic pathogenesis, providing insights into the underlying cellular and signaling mechanisms that will help guide future research into promising interventional targets with therapeutic potential.
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