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Assessment of Systemic Adenosine Effect Using Color Doppler Ultrasound of the Splenic Artery-Feasibility and

Oliver Klein-Wiele1, Walied Sherifa2, Marietta Garmer3

  • 1Grönemeyer Institut Bochum, University of Witten/Herdecke, Bochum, Germany; Department of Cardiology, University of Witten/Herdecke, Katholisches Klinikum Essen, Essen, Germany.

Ultrasound in Medicine & Biology
|March 6, 2018
PubMed

Insights

Adenosine infusion can reduce splanchnic perfusion, a response assessed via splenic artery velocity. This study demonstrates the feasibility of using Doppler ultrasound to monitor this effect in humans, aiding in assessing adenosine

Area of Science:

  • Cardiovascular medicine
  • Medical imaging
  • Pharmacology

Background:

  • Adenosine is known to cause coronary vasodilation and reduce splanchnic perfusion.
  • The effect of adenosine on splanchnic perfusion can be variable, with some individuals being non-responders.
  • Assessing splanchnic artery response to adenosine using imaging has not been previously performed in humans.

Purpose of the Study:

  • To assess the feasibility of using splenic artery color Doppler to evaluate adenosine-induced splanchnic perfusion changes in humans.
  • To correlate splenic artery velocity changes with magnetic resonance perfusion imaging during adenosine infusion.

Main Methods:

  • Twenty-six patients underwent splenic artery color Doppler ultrasound during adenosine infusion.
  • Peak splenic artery velocity was measured before and after 2 minutes of adenosine infusion.
  • Results were qualitatively compared with concurrent magnetic resonance perfusion imaging.

Main Results:

  • A significant drop in splenic artery peak velocity was observed in 24 out of 26 patients (from 62.3 ± 18.1 to 40.4 ± 15.7 cm/s, p < 0.001).
  • This velocity reduction correlated with observed perfusion restriction on magnetic resonance imaging.
  • Two patients with no change in splenic artery velocity did not exhibit perfusion restriction.

Conclusions:

  • This study demonstrates the feasibility of assessing changes in splenic artery velocity under adenosine in humans.
  • This novel application may serve as a tool to identify inadequate adenosine response during fractional flow reserve measurements.
  • Further research is warranted to validate this method for clinical use in coronary catheterization procedures.

Keywords:
AdenosineCardiovascular magnetic resonanceSplanchnic perfusionSplenic arterySplenic switch-off signStress perfusion

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