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Updated: Feb 13, 2026

Author Spotlight: Optimizing CFPS Systems for Synthetic Cell Construction
Published on: April 19, 2024
Synthetic efforts towards the stereoselective synthesis of NF00659B1
Do-Yeon Kwon1, Kiyoun Lee2, Hyeri Park1
1Department of Chemistry, Duke University, Durham, NC 27708, United States.
Abstract:
NF00659B1 is a novel α-pyrone diterpenoid natural product with potent anti-colon cancer activity. A stereoselective approach to the 2,2-dimethyl oxepanol core of NF00659B1 is described enlisting a sequence of olefinic ester ring-closing metathesis, epoxidation, and Grignard addition. This strategy paves the way to a total synthesis of NF00659B1 for further biological studies.
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