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Related Experiment Video

Updated: Feb 13, 2026

A Blood-Free Diet to Rear Anopheline Mosquitoes
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Do we choose control diets wisely?

Ana D Mandić1, Michael Blaut1

  • 1Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.

Trends in Endocrinology and Metabolism: TEM
|March 6, 2018
PubMed
Summary

Choosing the right control diet is crucial in nutrition and obesity research. Inadequate control diets, like standard chow, may skew results investigating gut microbiota and obesity development in animal studies.

Area of Science:

  • Nutritional Science
  • Microbiology
  • Obesity Research

Background:

  • Animal studies investigating nutrition, gut microbiota, and obesity often use standard chow as a control diet.
  • The composition of standard chow may significantly interact with dietary fat content, potentially confounding results.

Purpose of the Study:

  • To systematically compare the effects of refined high-fat (rHFD) and low-fat (rLFD) diets against standard chow.
  • To assess the impact of different control diets on mouse physiology, gut microbiota, and intestinal health.

Main Methods:

  • Comparison of refined high- and low-fat diets with standard chow in mice.
  • Analysis of physiological parameters, gut microbiota composition, cecal fermentation, and intestinal morphology.

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Main Results:

  • Refined diets (rHFD, rLFD) induced different physiological and microbiota changes compared to standard chow.
  • The choice of control diet significantly influences the interpretation of results in nutrition-obesity studies.

Conclusions:

  • Standard chow may not be an adequate control for studies using refined high- or low-fat diets.
  • Conclusions from prior studies comparing HFDs with chow diets may need re-evaluation due to potential control diet inadequacy.